Gene description for PIK3CD
Gene name phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
Gene symbol PIK3CD
Other names/aliases APDS
Species Homo sapiens
 Database cross references - PIK3CD
ExoCarta ExoCarta_5293
Entrez Gene 5293
HGNC 8977
MIM 602839
UniProt O00329  
 PIK3CD identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for PIK3CD
Molecular Function
    1-phosphatidylinositol-3-kinase activity GO:0016303 NAS
    ATP binding GO:0005524 IEA
    phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 IBA
    1-phosphatidylinositol-4-phosphate 3-kinase activity GO:0035005 IBA
    phosphatidylinositol 3-kinase activity GO:0035004 TAS
    protein binding GO:0005515 IPI
Biological Process
    mast cell differentiation GO:0060374 TAS
    T cell activation GO:0042110 TAS
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    adaptive immune response GO:0002250 TAS
    protein phosphorylation GO:0006468 NAS
    natural killer cell differentiation GO:0001779 TAS
    inflammatory response GO:0006954 TAS
    phospholipid metabolic process GO:0006644 TAS
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    T cell receptor signaling pathway GO:0050852 TAS
    B cell receptor signaling pathway GO:0050853 TAS
    T cell differentiation GO:0030217 TAS
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    mast cell degranulation GO:0043303 TAS
    T cell chemotaxis GO:0010818 TAS
    B cell activation GO:0042113 TAS
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    phosphatidylinositol phosphorylation GO:0046854 IBA
    cytokine production GO:0001816 TAS
    phosphatidylinositol-mediated signaling GO:0048015 TAS
    platelet activation GO:0030168 IBA
    respiratory burst involved in defense response GO:0002679 TAS
    small molecule metabolic process GO:0044281 TAS
    natural killer cell activation GO:0030101 TAS
    natural killer cell chemotaxis GO:0035747 TAS
    phosphatidylinositol 3-kinase signaling GO:0014065 TAS
    innate immune response GO:0045087 TAS
    B cell homeostasis GO:0001782 IEA
    phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 IBA
    signal transduction GO:0007165 NAS
    B cell chemotaxis GO:0035754 TAS
    neutrophil chemotaxis GO:0030593 TAS
    mast cell chemotaxis GO:0002551 TAS
    phosphatidylinositol biosynthetic process GO:0006661 TAS
    neutrophil extravasation GO:0072672 TAS
    positive regulation of gene expression GO:0010628 IMP
    positive regulation of cell migration GO:0030335 IMP
Subcellular Localization
    mast cell granule GO:0042629 TAS
    cytoplasm GO:0005737 IBA
    plasma membrane GO:0005886 TAS
    phosphatidylinositol 3-kinase complex GO:0005942 NAS
    cytosol GO:0005829 TAS
 Experiment description of studies that identified PIK3CD in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for PIK3CD
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PIK3R1 5295
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
2 PIK3CG  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
3 ASCC2  
Two-hybrid Homo sapiens
4 PIK3R2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
5 HRAS 3265
Two-hybrid Homo sapiens
View the network image/svg+xml

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