Gene description for PIK3CD
Gene name phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
Gene symbol PIK3CD
Other names/aliases APDS
IMD14
P110DELTA
PI3K
p110D
Species Homo sapiens
 Database cross references - PIK3CD
ExoCarta ExoCarta_5293
Vesiclepedia VP_5293
Entrez Gene 5293
HGNC 8977
MIM 602839
UniProt O00329  
 PIK3CD identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for PIK3CD
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    1-phosphatidylinositol-3-kinase activity GO:0016303 IBA
    1-phosphatidylinositol-3-kinase activity GO:0016303 NAS
    1-phosphatidylinositol-3-kinase activity GO:0016303 TAS
    1-phosphatidylinositol-4-phosphate 3-kinase activity GO:0035005 IBA
    1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 IEA
Biological Process
    natural killer cell differentiation GO:0001779 TAS
    positive regulation of cytokine production GO:0001819 TAS
    positive regulation of endothelial cell proliferation GO:0001938 IGI
    adaptive immune response GO:0002250 TAS
    mast cell chemotaxis GO:0002551 TAS
    respiratory burst involved in defense response GO:0002679 TAS
    protein phosphorylation GO:0006468 NAS
    inflammatory response GO:0006954 TAS
    immune response GO:0006955 NAS
    signal transduction GO:0007165 NAS
    positive regulation of endothelial cell migration GO:0010595 IGI
    positive regulation of gene expression GO:0010628 IMP
    T cell chemotaxis GO:0010818 TAS
    cell migration GO:0016477 IBA
    natural killer cell activation GO:0030101 TAS
    B cell differentiation GO:0030183 NAS
    T cell differentiation GO:0030217 NAS
    T cell differentiation GO:0030217 TAS
    positive regulation of cell migration GO:0030335 IMP
    neutrophil chemotaxis GO:0030593 TAS
    positive regulation of neutrophil apoptotic process GO:0033031 IMP
    natural killer cell chemotaxis GO:0035747 TAS
    B cell chemotaxis GO:0035754 TAS
    phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 IBA
    vascular endothelial growth factor signaling pathway GO:0038084 IGI
    T cell activation GO:0042110 TAS
    B cell activation GO:0042113 TAS
    mast cell degranulation GO:0043303 TAS
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IBA
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IGI
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IMP
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 TAS
    innate immune response GO:0045087 TAS
    positive regulation of angiogenesis GO:0045766 ISS
    phosphatidylinositol-mediated signaling GO:0048015 IBA
    T cell receptor signaling pathway GO:0050852 TAS
    B cell receptor signaling pathway GO:0050853 TAS
    mast cell differentiation GO:0060374 TAS
    neutrophil extravasation GO:0072672 TAS
    positive regulation of epithelial tube formation GO:1905278 IGI
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    phosphatidylinositol 3-kinase complex GO:0005942 IBA
    phosphatidylinositol 3-kinase complex GO:0005942 NAS
    phosphatidylinositol 3-kinase complex, class IA GO:0005943 IPI
    phosphatidylinositol 3-kinase complex, class IA GO:0005943 NAS
 Experiment description of studies that identified PIK3CD in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for PIK3CD
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TAGLN 6876
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
2 ASCC2 84164
Two-hybrid Homo sapiens
3 CRK 1398
Affinity Capture-MS Homo sapiens
4 PIK3R2 5296
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
5 PIK3R1 5295
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
6 PIK3CG  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
7 TNIP1 10318
Affinity Capture-Western Homo sapiens
8 HRAS 3265
Two-hybrid Homo sapiens
9 ZDHHC23  
Affinity Capture-MS Homo sapiens
10 ZDHHC18 84243
Affinity Capture-MS Homo sapiens
11 PIK3R3 8503
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
12 AKT2 208
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which PIK3CD is involved
PathwayEvidenceSource
Adaptive Immune System TAS Reactome
Adaptive Immune System IEA Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers TAS Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers IEA Reactome
Axon guidance TAS Reactome
Cellular responses to mechanical stimuli IEA Reactome
Cellular responses to stimuli IEA Reactome
Constitutive Signaling by Aberrant PI3K in Cancer TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Cytokine Signaling in Immune system IEA Reactome
Developmental Biology TAS Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) TAS Reactome
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) IEA Reactome
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells IEA Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Interleukin receptor SHC signaling TAS Reactome
Interleukin-2 family signaling TAS Reactome
Interleukin-3, Interleukin-5 and GM-CSF signaling TAS Reactome
Interleukin-3, Interleukin-5 and GM-CSF signaling IEA Reactome
Intracellular signaling by second messengers TAS Reactome
Metabolism TAS Reactome
Metabolism of lipids TAS Reactome
Negative regulation of the PI3K/AKT network TAS Reactome
Nervous system development TAS Reactome
Phospholipid metabolism TAS Reactome
PI Metabolism TAS Reactome
PI3K/AKT Signaling in Cancer TAS Reactome
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TAS Reactome
PIP3 activates AKT signaling TAS Reactome
Regulation of signaling by CBL IEA Reactome
Regulation of signaling by CBL TAS Reactome
Response of endothelial cells to shear stress IEA Reactome
RET signaling TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by CSF1 (M-CSF) in myeloid cells IEA Reactome
Signaling by Erythropoietin TAS Reactome
Signaling by Erythropoietin IEA Reactome
Signaling by Interleukins TAS Reactome
Signaling by Interleukins IEA Reactome
Signaling by the B Cell Receptor (BCR) TAS Reactome
Signaling by the B Cell Receptor (BCR) IEA Reactome
Synthesis of PIPs at the plasma membrane TAS Reactome





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