Gene description for CCR5
Gene name chemokine (C-C motif) receptor 5 (gene/pseudogene)
Gene symbol CCR5
Other names/aliases CC-CKR-5
Species Homo sapiens
 Database cross references - CCR5
ExoCarta ExoCarta_1234
Entrez Gene 1234
HGNC 1606
MIM 601373
UniProt P51681  
 CCR5 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for CCR5
Molecular Function
    actin binding GO:0003779 IDA
    C-C chemokine binding GO:0019957 IPI
    phosphatidylinositol phospholipase C activity GO:0004435 TAS
    chemokine (C-C motif) ligand 5 binding GO:0071791 IPI
    protein binding GO:0005515 IPI
    chemokine receptor activity GO:0004950 TAS
    coreceptor activity GO:0015026 TAS
    C-C chemokine receptor activity GO:0016493 NAS
Biological Process
    cell surface receptor signaling pathway GO:0007166 TAS
    chemotaxis GO:0006935 TAS
    dendritic cell chemotaxis GO:0002407 TAS
    chemokine-mediated signaling pathway GO:0070098 TAS
    entry into host cell GO:0030260 TAS
    signaling GO:0023052 IEP
    inflammatory response GO:0006954 IEA
    release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 IDA
    calcium-mediated signaling GO:0019722 IDA
    response to cholesterol GO:0070723 IMP
    cellular defense response GO:0006968 TAS
    viral process GO:0016032 TAS
    MAPK cascade GO:0000165 IEP
    cell-cell signaling GO:0007267 IDA
    calcium ion transport GO:0006816 IDA
    immune response GO:0006955 IEA
    G-protein coupled receptor signaling pathway GO:0007186 IMP
    cellular response to lipopolysaccharide GO:0071222 IEP
    positive regulation of cytosolic calcium ion concentration GO:0007204 TAS
Subcellular Localization
    endosome GO:0005768 IDA
    external side of plasma membrane GO:0009897 IDA
    cell surface GO:0009986 IDA
    integral component of plasma membrane GO:0005887 TAS
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 TAS
    cytoplasm GO:0005737 TAS
 Experiment description of studies that identified CCR5 in exosomes
Experiment ID 126
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for CCR5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CCL3  
Reconstituted Complex Homo sapiens
2 CD4 920
Affinity Capture-Western Homo sapiens
3 CCL8  
Invivo Homo sapiens
4 CCL5  
Invivo Homo sapiens
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
5 CCR2  
Invivo Homo sapiens
6 CCL3L1  
Reconstituted Complex Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
7 AFP 174
Affinity Capture-Western Homo sapiens
8 CXCR4 7852
Reconstituted Complex Homo sapiens
9 ARRB1 408
Reconstituted Complex Homo sapiens
10 PTK2 5747
Affinity Capture-Western Homo sapiens
11 CCL14  
Invivo Homo sapiens
Invitro Homo sapiens
12 CCL16  
Invivo Homo sapiens
13 PTK2B 2185
Invivo Homo sapiens
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