Gene description for CD247
Gene name
CD247 molecule
Gene symbol
CD247
Other names/aliases
CD3-ZETA CD3H CD3Q CD3Z IMD25 T3Z TCRZ
Species
Homo sapiens
Database cross references - CD247
ExoCarta
ExoCarta_919
Entrez Gene
919
HGNC
1677
MIM
186780
UniProt
P20963
CD247 identified in exosomes derived from the following tissue/cell type
Bone marrow cells
15908444
T cells
11907077
T cells
11907077
Thymus
23844026
Gene ontology annotations for CD247
Experiment description of studies that identified CD247 in exosomes
1
Experiment ID
42
ISEV standards
✔
EM
EV Biophysical techniques
✘
EV Cytosolic markers
✔
CD86|TFRC|LAMP2|ITGA2B|CD63|CD9|MHCI|CD81
EV Membrane markers
✔
CANX
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Western blotting
PubMed ID
15908444
Organism
Homo sapiens
Experiment description
Exosomal-like vesicles are present in human blood plasma.
Authors
Caby MP, Lankar D, Vincendeau-Scherrer C, Raposo G, Bonnerot C
Journal name
INTIMM
Publication year
2005
Sample
Bone marrow cells
Sample name
PBMC
Isolation/purification methods
Differential centrifugation Filtration Sucrose density gradient
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Western blotting
2
Experiment ID
17
ISEV standards
✔
EM
EV Biophysical techniques
✘
EV Cytosolic markers
✔
CD63
EV Membrane markers
✘
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Western blotting Immunoelectron Microscopy
PubMed ID
11907077
Organism
Homo sapiens
Experiment description
TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/zeta complex.
Authors
Blanchard N, Lankar D, Faure F, Regnault A, Dumont C, Raposo G, Hivroz C
Journal name
JIMMU
Publication year
2002
Sample
T cells
Sample name
Jurkat T cell blasts E+ cells MART-1+ T cell
Isolation/purification methods
Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Western blotting Immunoelectron Microscopy
3
Experiment ID
18
ISEV standards
✔
EM
EV Biophysical techniques
✘
EV Cytosolic markers
✔
CD63
EV Membrane markers
✘
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
FACS
PubMed ID
11907077
Organism
Homo sapiens
Experiment description
TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/zeta complex.
Authors
Blanchard N, Lankar D, Faure F, Regnault A, Dumont C, Raposo G, Hivroz C
Journal name
JIMMU
Publication year
2002
Sample
T cells
Sample name
Jurkat T cell blasts
Isolation/purification methods
Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
FACS
4
Experiment ID
217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23844026
Organism
Homo sapiens
Experiment description
Characterization of human thymic exosomes.
Authors
Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name
PLoS One
Publication year
2013
Sample
Thymus
Sample name
Normal-Thymus
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
Protein-protein interactions for CD247
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
SLA2
84174
Invivo
Homo sapiens
2
PTPRC
5788
Reconstituted Complex
Homo sapiens
3
TFRC
7037
Invivo
Homo sapiens
Invitro
Homo sapiens
Affinity Capture-MS
Homo sapiens
4
SHC1
6464
Invivo
Homo sapiens
Affinity Capture-MS
Homo sapiens
5
STAT5B
6777
Invivo
Homo sapiens
6
CD3D
915
Invivo
Homo sapiens
Invitro
Homo sapiens
7
STAT5A
6776
Invivo
Homo sapiens
Affinity Capture-MS
Homo sapiens
8
TRA@
Invivo
Homo sapiens
Affinity Capture-MS
Homo sapiens
9
SLA
Affinity Capture-Western
Homo sapiens
Affinity Capture-MS
Homo sapiens
10
TRAT1
50852
Affinity Capture-MS
Homo sapiens
Affinity Capture-Western
Homo sapiens
11
UNC119
Affinity Capture-Western
Homo sapiens
Reconstituted Complex
Homo sapiens
Affinity Capture-MS
Homo sapiens
12
GAB2
9846
Affinity Capture-Western
Homo sapiens
13
CD247
919
Invivo
Homo sapiens
Affinity Capture-MS
Homo sapiens
Invivo
Homo sapiens
Affinity Capture-MS
Homo sapiens
14
JAK3
3718
Invivo
Homo sapiens
Invitro
Homo sapiens
Affinity Capture-MS
Homo sapiens
15
CD5
921
Invivo
Homo sapiens
Invitro
Homo sapiens
16
FYN
2534
Affinity Capture-MS
Homo sapiens
17
NCR1
Affinity Capture-Western
Homo sapiens
18
ZAP70
7535
Affinity Capture-MS
Homo sapiens
19
LNK
Affinity Capture-MS
Homo sapiens
20
CD2
914
Affinity Capture-MS
Homo sapiens
Invivo
Homo sapiens
Invitro
Homo sapiens
21
DOCK2
1794
Invivo
Homo sapiens
22
CD3E
916
Invivo
Homo sapiens
23
ATXN2
Affinity Capture-Western
Homo sapiens
24
TIRAP
Affinity Capture-MS
Homo sapiens
View the network
image/svg+xml
Pathways in which CD247 is involved
No pathways found