Gene description for PTPRC
Gene name	protein tyrosine phosphatase, receptor type, C
Gene symbol	PTPRC
Other names/aliases	B220 CD45 CD45R GP180 L-CA LCA LY5 T200
Species	Homo sapiens
Database cross references - PTPRC
ExoCarta	ExoCarta_5788
Entrez Gene	5788
HGNC	9666
MIM	151460
UniProt	P08575
PTPRC identified in exosomes derived from the following tissue/cell type
B cells	12519789
B cells	20458337
B cells	20458337
B cells	20458337
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Platelets	25332113
Platelets	25332113
Platelets	25332113
Thymus	23844026

Gene ontology annotations for PTPRC

Molecular Function     transmembrane receptor protein tyrosine phosphatase activity GO:0005001 TAS     protein kinase binding GO:0019901 IPI     protein binding GO:0005515 IPI     protein tyrosine phosphatase activity GO:0004725 IDA Biological Process     positive regulation of antigen receptor-mediated signaling pathway GO:0050857 ISS     protein dephosphorylation GO:0006470 ISS     positive regulation of stem cell proliferation GO:2000648 IMP     positive regulation of protein kinase activity GO:0045860 NAS     positive regulation of hematopoietic stem cell migration GO:2000473 IMP     T cell receptor signaling pathway GO:0050852 TAS     regulation of cell cycle GO:0051726 ISS     release of sequestered calcium ion into cytosol GO:0051209 ISS     bone marrow development GO:0048539 IMP     axon guidance GO:0007411 TAS     negative regulation of T cell mediated cytotoxicity GO:0001915 ISS     defense response to virus GO:0051607 ISS     cell surface receptor signaling pathway GO:0007166 TAS     negative regulation of cytokine-mediated signaling pathway GO:0001960 ISS     hematopoietic progenitor cell differentiation GO:0002244 IMP     stem cell development GO:0048864 IMP     cell cycle phase transition GO:0044770 IMP     positive regulation of T cell proliferation GO:0042102 ISS     positive regulation of B cell proliferation GO:0030890 IMP     T cell differentiation GO:0030217 ISS     dephosphorylation GO:0016311 ISS     B cell receptor signaling pathway GO:0050853 ISS     negative regulation of protein kinase activity GO:0006469 ISS     negative regulation of cell adhesion involved in substrate-bound cell migration GO:0006933 IMP     peptidyl-tyrosine dephosphorylation GO:0035335 TAS     immunoglobulin biosynthetic process GO:0002378 IMP     B cell proliferation GO:0042100 ISS Subcellular Localization     cell surface GO:0009986 IDA     focal adhesion GO:0005925 ISS     extracellular exosome GO:0070062 IDA     integral component of plasma membrane GO:0005887 ISS     external side of plasma membrane GO:0009897 IDA     membrane raft GO:0045121 IEA     membrane GO:0016020 IDA     plasma membrane GO:0005886 TAS     intracellular GO:0005622 ISS