Gene description for CD38
Gene name CD38 molecule
Gene symbol CD38
Other names/aliases ADPRC 1
T10
Species Homo sapiens
 Database cross references - CD38
ExoCarta ExoCarta_952
Entrez Gene 952
HGNC 1667
MIM 107270
UniProt P28907  
 CD38 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for CD38
Molecular Function
    transferase activity GO:0016740 IEA
    NAD+ nucleosidase activity GO:0003953 IBA
    NAD(P)+ nucleosidase activity GO:0050135 IEA
    phosphorus-oxygen lyase activity GO:0016849 IBA
Biological Process
    response to drug GO:0042493 IMP
    positive regulation of cytosolic calcium ion concentration GO:0007204 IEA
    signal transduction GO:0007165 NAS
    response to hypoxia GO:0001666 IEA
    female pregnancy GO:0007565 IEA
    positive regulation of vasoconstriction GO:0045907 IEA
    B cell receptor signaling pathway GO:0050853 IMP
    response to interleukin-1 GO:0070555 IEA
    response to progesterone GO:0032570 IEA
    negative regulation of apoptotic process GO:0043066 IMP
    metabolic process GO:0008152 IBA
    positive regulation of insulin secretion GO:0032024 IEA
    response to retinoic acid GO:0032526 IEA
    negative regulation of bone resorption GO:0045779 IEA
    long term synaptic depression GO:0060292 IEA
    positive regulation of transcription, DNA-templated GO:0045893 IMP
    positive regulation of B cell proliferation GO:0030890 IMP
    response to hydroperoxide GO:0033194 IEA
    positive regulation of cell growth GO:0030307 IEA
    negative regulation of transcription, DNA-templated GO:0045892 IMP
    apoptotic signaling pathway GO:0097190 TAS
    response to estradiol GO:0032355 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    membrane GO:0016020 TAS
    extracellular exosome GO:0070062 IDA
    cell surface GO:0009986 IEA
    plasma membrane GO:0005886 IEA
    cytosol GO:0005829 IEA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified CD38 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 196
ISEV standards
EM
EV Biophysical techniques
Alix|TSG101|HSP70
EV Cytosolic markers
CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 197
ISEV standards
EM
EV Biophysical techniques
Alix|TSG101|HSP70
EV Cytosolic markers
CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CD38
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FCGR3A  
Affinity Capture-MS Homo sapiens
FRET Homo sapiens
2 LCK 3932
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
3 CD4 920
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which CD38 is involved
No pathways found





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