Gene description for PDCD4
Gene name
programmed cell death 4 (neoplastic transformation inhibitor)
Gene symbol
PDCD4
Other names/aliases
H731
Species
Homo sapiens
Database cross references - PDCD4
ExoCarta
ExoCarta_27250
Entrez Gene
27250
HGNC
8763
MIM
608610
UniProt
Q53EL6
PDCD4 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells
23333927
Ovarian cancer cells
23333927
Thymus
23844026
Gene ontology annotations for PDCD4
Experiment description of studies that identified PDCD4 in exosomes
1
Experiment ID
211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23333927
Organism
Homo sapiens
Experiment description
Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors
Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name
J Proteomics
Publication year
2013
Sample
Ovarian cancer cells
Sample name
IGROV1
Isolation/purification methods
Differential centrifugation Ultracentrifugation Sucrose density gradient
Flotation density
1.09-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
2
Experiment ID
212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23333927
Organism
Homo sapiens
Experiment description
Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors
Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name
J Proteomics
Publication year
2013
Sample
Ovarian cancer cells
Sample name
OVCAR-3
Isolation/purification methods
Differential centrifugation Ultracentrifugation Sucrose density gradient
Flotation density
1.09-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
3
Experiment ID
217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23844026
Organism
Homo sapiens
Experiment description
Characterization of human thymic exosomes.
Authors
Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name
PLoS One
Publication year
2013
Sample
Thymus
Sample name
Normal-Thymus
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
Protein-protein interactions for PDCD4
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
EIF4A2
1974
Affinity Capture-MS
Homo sapiens
2
RPLP1
6176
Affinity Capture-MS
Homo sapiens
3
RPL5
6125
Affinity Capture-MS
Homo sapiens
Reconstituted Complex
Homo sapiens
Two-hybrid
Homo sapiens
4
TI-227H
Two-hybrid
Homo sapiens
5
EIF4A1
1973
Affinity Capture-MS
Homo sapiens
6
RPS13
6207
Affinity Capture-MS
Homo sapiens
Reconstituted Complex
Homo sapiens
Two-hybrid
Homo sapiens
7
EIF4G1
1981
Affinity Capture-Western
Homo sapiens
View the network
image/svg+xml
Pathways in which PDCD4 is involved
No pathways found