Gene description for RPS6KA1
Gene name	ribosomal protein S6 kinase, 90kDa, polypeptide 1
Gene symbol	RPS6KA1
Other names/aliases	HU-1 MAPKAPK1A RSK RSK1 p90Rsk
Species	Homo sapiens
Database cross references - RPS6KA1
ExoCarta	ExoCarta_6195
Entrez Gene	6195
HGNC	10430
MIM	601684
UniProt	Q15418
RPS6KA1 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Thymus	23844026

Gene ontology annotations for RPS6KA1

Molecular Function     protein serine/threonine/tyrosine kinase activity GO:0004712 IDA     ATP binding GO:0005524 IEA     protein binding GO:0005515 IPI     cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027 IDA     magnesium ion binding GO:0000287 IEA     ribosomal protein S6 kinase activity GO:0004711 IBA     protein serine/threonine kinase activity GO:0004674 IDA Biological Process     innate immune response GO:0045087 TAS     toll-like receptor 2 signaling pathway GO:0034134 TAS     toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 TAS     synaptic transmission GO:0007268 TAS     cell cycle GO:0007049 IEA     toll-like receptor 10 signaling pathway GO:0034166 TAS     toll-like receptor 3 signaling pathway GO:0034138 TAS     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     signal transduction GO:0007165 TAS     positive regulation of cell differentiation GO:0045597 TAS     positive regulation of cell growth GO:0030307 TAS     negative regulation of apoptotic process GO:0043066 IMP     intracellular signal transduction GO:0035556 IBA     regulation of translation in response to stress GO:0043555 TAS     MyD88-dependent toll-like receptor signaling pathway GO:0002755 TAS     toll-like receptor 9 signaling pathway GO:0034162 TAS     toll-like receptor 5 signaling pathway GO:0034146 TAS     regulation of DNA-templated transcription in response to stress GO:0043620 TAS     negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 IDA     positive regulation of hepatic stellate cell activation GO:2000491 IMP     toll-like receptor signaling pathway GO:0002224 TAS     protein phosphorylation GO:0006468 IBA     hepatocyte proliferation GO:0072574 ISS     stress-activated MAPK cascade GO:0051403 TAS     MyD88-independent toll-like receptor signaling pathway GO:0002756 TAS     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP     toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 TAS     axon guidance GO:0007411 TAS     toll-like receptor 4 signaling pathway GO:0034142 TAS     TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS Subcellular Localization     cytosol GO:0005829 TAS     spindle GO:0005819 IEA     cytoplasm GO:0005737 IDA     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 TAS