Gene description for GGA2
Gene name golgi-associated, gamma adaptin ear containing, ARF binding protein 2
Gene symbol GGA2
Other names/aliases VEAR
Species Homo sapiens
 Database cross references - GGA2
ExoCarta ExoCarta_23062
Vesiclepedia VP_23062
Entrez Gene 23062
HGNC 16064
MIM 606005
UniProt Q9UJY4  
 GGA2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for GGA2
Molecular Function
    ADP-ribosylation factor binding GO:0030306 IDA
    protein binding GO:0005515 IPI
Biological Process
    vesicle-mediated transport GO:0016192 IEA
    intracellular protein transport GO:0006886 NAS
Subcellular Localization
    endosome membrane GO:0010008 IEA
    trans-Golgi network GO:0005802 IDA
    Golgi apparatus GO:0005794 IDA
    clathrin-coated vesicle GO:0030136 IDA
    clathrin adaptor complex GO:0030131 IEA
 Experiment description of studies that identified GGA2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for GGA2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PIN1 5300
Two-hybrid Homo sapiens
2 GGA2 23062
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 M6PR 4074
Two-hybrid Homo sapiens
4 SPG21 51324
Two-hybrid Homo sapiens
5 CLTC 1213
Reconstituted Complex Homo sapiens
6 NECAP2 55707
Affinity Capture-Western Homo sapiens
7 ARF3 377
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
8 CLINT1 9685
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
9 TRIM23 373
Two-hybrid Homo sapiens
10 SORL1 6653
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
11 SORT1 6272
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
12 RAB5A 5868
Two-hybrid Homo sapiens
13 RABEP1 9135
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
14 IGF2R 3482
Invitro Homo sapiens
15 BACE1  
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which GGA2 is involved
No pathways found





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