Gene description for GGA2
Gene name golgi-associated, gamma adaptin ear containing, ARF binding protein 2
Gene symbol GGA2
Other names/aliases VEAR
Species Homo sapiens
 Database cross references - GGA2
ExoCarta ExoCarta_23062
Vesiclepedia VP_23062
Entrez Gene 23062
HGNC 16064
MIM 606005
UniProt Q9UJY4  
 GGA2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for GGA2
Molecular Function
    protein binding GO:0005515 IPI
    small GTPase binding GO:0031267 IBA
    small GTPase binding GO:0031267 IDA
    phosphatidylinositol binding GO:0035091 IEA
    ubiquitin binding GO:0043130 IEA
Biological Process
    intracellular protein transport GO:0006886 NAS
    Golgi to plasma membrane transport GO:0006893 IBA
    protein localization to cell surface GO:0034394 IBA
    protein localization to cell surface GO:0034394 IDA
    Golgi to plasma membrane protein transport GO:0043001 IDA
Subcellular Localization
    Golgi apparatus GO:0005794 IDA
    trans-Golgi network GO:0005802 IBA
    trans-Golgi network GO:0005802 IDA
    endosome membrane GO:0010008 TAS
    clathrin-coated vesicle GO:0030136 IDA
    early endosome membrane GO:0031901 TAS
 Experiment description of studies that identified GGA2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for GGA2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SYNRG 11276
Affinity Capture-Western Homo sapiens
2 ITGB1 3688
Affinity Capture-Western Homo sapiens
3 MBOAT7 79143
Proximity Label-MS Homo sapiens
4 ATXN1 6310
Two-hybrid Homo sapiens
5 GGA3 23163
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
6 AP2B1 163
Proximity Label-MS Homo sapiens
7 STAB1  
Reconstituted Complex Homo sapiens
8 RNF11 26994
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
9 CLINT1 9685
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 SORL1 6653
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
11 XPO1 7514
Affinity Capture-MS Homo sapiens
12 NINL  
Proximity Label-MS Homo sapiens
13 BACE1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
14 PIN1 5300
Two-hybrid Homo sapiens
15 CLTA 1211
Proximity Label-MS Homo sapiens
16 RTN4IP1  
Two-hybrid Homo sapiens
17 TOLLIP 54472
Reconstituted Complex Homo sapiens
18 M6PR 4074
Two-hybrid Homo sapiens
19 SPG21 51324
Two-hybrid Homo sapiens
20 ARF3 377
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
21 ATG9A 79065
Proximity Label-MS Homo sapiens
22 EGFR 1956
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
23 ARF1 375
Reconstituted Complex Homo sapiens
24 MAP3K1 4214
Biochemical Activity Homo sapiens
25 ARF6 382
Proximity Label-MS Homo sapiens
26 RABEP1 9135
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 ARF4 378
Proximity Label-MS Homo sapiens
28 APP 351
Reconstituted Complex Homo sapiens
29 LRP10 26020
Proximity Label-MS Homo sapiens
30 HTT 3064
Two-hybrid Homo sapiens
31 NECAP2 55707
Affinity Capture-Western Homo sapiens
32 ARHGAP29 9411
Proximity Label-MS Homo sapiens
33 MEMO1 51072
Two-hybrid Homo sapiens
34 GOLGA5 9950
Proximity Label-MS Homo sapiens
35 VCP 7415
Affinity Capture-MS Homo sapiens
36 BACE2 25825
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
37 SORT1 6272
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
38 RAB13 5872
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
39 CA8  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
40 IGF2R 3482
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
41 SEC23B 10483
Affinity Capture-Western Homo sapiens
42 HGS 9146
Reconstituted Complex Homo sapiens
43 ZBED6 100381270
Proximity Label-MS Homo sapiens
44 MAP1A 4130
Affinity Capture-MS Homo sapiens
45 HTR5BP  
Proximity Label-MS Homo sapiens
46 CLTC 1213
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
47 PTRF 284119
Proximity Label-MS Homo sapiens
48 RAB10 10890
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
49 PHLDB2 90102
Proximity Label-MS Homo sapiens
50 PICALM 8301
Proximity Label-MS Homo sapiens
51 GGA1 26088
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 VPS18 57617
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
53 CPLX1 10815
Co-fractionation Homo sapiens
54 RPS6KA1 6195
Proximity Label-MS Homo sapiens
55 TRIM23 373
Two-hybrid Homo sapiens
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