Gene description for TPD52
Gene name tumor protein D52
Gene symbol TPD52
Other names/aliases D52
N8L
PC-1
PrLZ
hD52
Species Homo sapiens
 Database cross references - TPD52
ExoCarta ExoCarta_7163
Entrez Gene 7163
HGNC 12005
MIM 604068
UniProt P55327  
 TPD52 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for TPD52
Molecular Function
    protein homodimerization activity GO:0042803 IDA
    protein heterodimerization activity GO:0046982 IDA
    protein binding GO:0005515 IPI
    calcium ion binding GO:0005509 IDA
Biological Process
    B cell differentiation GO:0030183 IEP
    secretion GO:0046903 TAS
    anatomical structure morphogenesis GO:0009653 TAS
Subcellular Localization
    perinuclear region of cytoplasm GO:0048471 IDA
    cytoplasm GO:0005737 IDA
    endoplasmic reticulum GO:0005783 IDA
 Experiment description of studies that identified TPD52 in exosomes
1
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for TPD52
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TPD52L1 7164
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
2 MAL2 114569
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
3 TPD52 7163
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TPD52 is involved
PathwayEvidenceSource
Golgi Associated Vesicle Biogenesis TAS Reactome





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