Gene description for SLC18B1
Gene name solute carrier family 18, subfamily B, member 1
Gene symbol SLC18B1
Other names/aliases C6orf192
dJ55C23.6
Species Homo sapiens
 Database cross references - SLC18B1
ExoCarta ExoCarta_116843
Vesiclepedia VP_116843
Entrez Gene 116843
HGNC 21573
MIM 613361
UniProt Q6NT16  
 SLC18B1 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for SLC18B1
Molecular Function
    monoamine:proton antiporter activity GO:0015311 IDA
    polyamine:proton antiporter activity GO:0015312 IDA
    transmembrane transporter activity GO:0022857 IBA
Biological Process
    spermine transport GO:0000296 IDA
    spermidine transport GO:0015848 IDA
    serotonin uptake GO:0051610 IDA
    polyamine transmembrane transport GO:1902047 IEA
    proton transmembrane transport GO:1902600 IEA
Subcellular Localization
    secretory granule membrane GO:0030667 ISS
    synaptic vesicle membrane GO:0030672 ISS
 Experiment description of studies that identified SLC18B1 in exosomes
1
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SLC18B1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LAMTOR5 10542
Affinity Capture-MS Homo sapiens
2 F2RL1  
Two-hybrid Homo sapiens
3 BACH1 571
Affinity Capture-MS Homo sapiens
4 LAMP1 3916
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 USP10 9100
Affinity Capture-MS Homo sapiens
6 LAMTOR2 28956
Affinity Capture-MS Homo sapiens
7 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
View the network image/svg+xml
 Pathways in which SLC18B1 is involved
No pathways found





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