Gene description for ADAM30
Gene name ADAM metallopeptidase domain 30
Gene symbol ADAM30
Other names/aliases svph4
Species Homo sapiens
 Database cross references - ADAM30
ExoCarta ExoCarta_11085
Vesiclepedia VP_11085
Entrez Gene 11085
HGNC 208
MIM 604779
UniProt Q9UKF2  
 ADAM30 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for ADAM30
Molecular Function
    metalloendopeptidase activity GO:0004222 IBA
    metallopeptidase activity GO:0008237 TAS
    zinc ion binding GO:0008270 TAS
Biological Process
    proteolysis GO:0006508 IBA
    male gonad development GO:0008584 IBA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IBA
    membrane GO:0016020 TAS
    late endosome membrane GO:0031902 IEA
    sperm head plasma membrane GO:1990913 IBA
 Experiment description of studies that identified ADAM30 in exosomes
1
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for ADAM30
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC11C 90701
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 SGCB 6443
Affinity Capture-MS Homo sapiens
3 TTC13  
Affinity Capture-MS Homo sapiens
4 FOXF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 IL17RA 23765
Affinity Capture-MS Homo sapiens
6 DGCR2 9993
Affinity Capture-MS Homo sapiens
7 SCNN1A  
Affinity Capture-MS Homo sapiens
8 LCLAT1 253558
Affinity Capture-MS Homo sapiens
9 ITGB5 3693
Affinity Capture-MS Homo sapiens
10 P4HTM  
Affinity Capture-MS Homo sapiens
11 CANX 821
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 SLC39A6 25800
Affinity Capture-MS Homo sapiens
13 PBXIP1 57326
Affinity Capture-MS Homo sapiens
14 SEC11A 23478
Affinity Capture-MS Homo sapiens
15 GLT8D1 55830
Affinity Capture-MS Homo sapiens
16 PON2 5445
Affinity Capture-MS Homo sapiens
17 TOR4A 54863
Affinity Capture-MS Homo sapiens
18 NR3C1 2908
Proximity Label-MS Homo sapiens
19 STIM1 6786
Affinity Capture-MS Homo sapiens
20 MR1  
Affinity Capture-MS Homo sapiens
21 ADAM10 102
Affinity Capture-MS Homo sapiens
22 ITGB4 3691
Affinity Capture-MS Homo sapiens
23 ADAMTS2 9509
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 MBTPS2  
Affinity Capture-MS Homo sapiens
25 MIA3 375056
Affinity Capture-MS Homo sapiens
26 ROR2 4920
Affinity Capture-MS Homo sapiens
27 USP30  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 MUSK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 ST14 6768
Affinity Capture-MS Homo sapiens
30 EXT2 2132
Affinity Capture-MS Homo sapiens
31 MTF2  
Affinity Capture-MS Homo sapiens
32 SCARA3  
Affinity Capture-MS Homo sapiens
33 LRP6 4040
Affinity Capture-MS Homo sapiens
34 LRP5 4041
Affinity Capture-MS Homo sapiens
35 SUN2 25777
Affinity Capture-MS Homo sapiens
36 CLSTN3 9746
Affinity Capture-MS Homo sapiens
37 HLA-F 3134
Affinity Capture-MS Homo sapiens
38 SPCS1 28972
Affinity Capture-MS Homo sapiens
39 LAMB3 3914
Affinity Capture-MS Homo sapiens
40 FRAS1 80144
Affinity Capture-MS Homo sapiens
41 JAG2  
Affinity Capture-MS Homo sapiens
42 LDLR 3949
Affinity Capture-MS Homo sapiens
43 LOC100507703  
Affinity Capture-MS Homo sapiens
44 PLXNA2 5362
Affinity Capture-MS Homo sapiens
45 SUSD2 56241
Affinity Capture-MS Homo sapiens
46 HLA-A 3105
Affinity Capture-MS Homo sapiens
47 TMEM131  
Affinity Capture-MS Homo sapiens
48 SEMA6A  
Affinity Capture-MS Homo sapiens
49 METTL7B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 SPCS2 9789
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 DNAJC16  
Affinity Capture-MS Homo sapiens
52 HLA-C 3107
Affinity Capture-MS Homo sapiens
53 PRF1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ADAM30 is involved
PathwayEvidenceSource
Fertilization TAS Reactome
Interaction With Cumulus Cells And The Zona Pellucida TAS Reactome
Reproduction TAS Reactome





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