Gene description for ADAM30
Gene name ADAM metallopeptidase domain 30
Gene symbol ADAM30
Other names/aliases svph4
Species Homo sapiens
 Database cross references - ADAM30
ExoCarta ExoCarta_11085
Vesiclepedia VP_11085
Entrez Gene 11085
HGNC 208
MIM 604779
UniProt Q9UKF2  
 ADAM30 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for ADAM30
Molecular Function
    metalloendopeptidase activity GO:0004222 IEA
    zinc ion binding GO:0008270 IEA
    metallopeptidase activity GO:0008237 TAS
Biological Process
    proteolysis GO:0006508 IEA
    binding of sperm to zona pellucida GO:0007339 TAS
    multicellular organism reproduction GO:0032504 TAS
    single fertilization GO:0007338 TAS
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified ADAM30 in exosomes
1
Experiment ID 275
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
EV Enriched markers
✔
AIF
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for ADAM30
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ADAM30 is involved
PathwayEvidenceSource
Interaction With The Zona Pellucida TAS Reactome





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