Gene description for ADAMTS2
Gene name ADAM metallopeptidase with thrombospondin type 1 motif, 2
Gene symbol ADAMTS2
Other names/aliases ADAM-TS2
ADAMTS-2
ADAMTS-3
NPI
PC I-NP
PCI-NP
PCINP
PCPNI
PNPI
Species Homo sapiens
 Database cross references - ADAMTS2
ExoCarta ExoCarta_9509
Entrez Gene 9509
HGNC 218
MIM 604539
UniProt O95450  
 ADAMTS2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for ADAMTS2
Molecular Function
    metalloendopeptidase activity GO:0004222 IEA
    metallopeptidase activity GO:0008237 TAS
    zinc ion binding GO:0008270 IEA
Biological Process
    skin development GO:0043588 IEA
    lung development GO:0030324 IEA
    collagen catabolic process GO:0030574 IEA
    extracellular matrix organization GO:0030198 TAS
    spermatogenesis GO:0007283 IEA
    collagen fibril organization GO:0030199 IEA
    protein processing GO:0016485 IEA
Subcellular Localization
    proteinaceous extracellular matrix GO:0005578 IEA
    extracellular region GO:0005576 TAS
 Experiment description of studies that identified ADAMTS2 in exosomes
1
Experiment ID 224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for ADAMTS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ADAMTS2 is involved
PathwayEvidenceSource
Collagen biosynthesis and modifying enzymes TAS Reactome
O-glycosylation of TSR domain-containing proteins TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here