Gene description for WNT10B
Gene name wingless-type MMTV integration site family, member 10B
Gene symbol WNT10B
Other names/aliases SHFM6
WNT-12
Species Homo sapiens
 Database cross references - WNT10B
ExoCarta ExoCarta_7480
Entrez Gene 7480
HGNC 12775
MIM 601906
UniProt O00744  
 WNT10B identified in exosomes derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for WNT10B
Molecular Function
    frizzled binding GO:0005109 IBA
    receptor agonist activity GO:0048018 IC
Biological Process
    hematopoietic stem cell proliferation GO:0071425 IDA
    smoothened signaling pathway GO:0007224 IEA
    myoblast differentiation involved in skeletal muscle regeneration GO:0014835 IEA
    protein stabilization GO:0050821 IDA
    cellular response to hydrostatic pressure GO:0071464 IEA
    regulation of skeletal muscle tissue development GO:0048641 IEA
    fungiform papilla development GO:0061196 IEA
    skeletal muscle fiber development GO:0048741 IEA
    positive regulation of apoptotic process GO:0043065 IMP
    sensory perception of taste GO:0050909 IEA
    positive regulation of osteoblast differentiation GO:0045669 IEA
    positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 IEA
    cellular response to parathyroid hormone stimulus GO:0071374 IEA
    cellular response to cAMP GO:0071320 IEA
    lipid metabolic process GO:0006629 IEA
    canonical Wnt signaling pathway GO:0060070 IDA
    chondrocyte differentiation GO:0002062 IEP
    G2/M transition of mitotic cell cycle GO:0000086 IEA
    positive regulation of anagen GO:0051885 IEA
    negative regulation of fat cell differentiation GO:0045599 IDA
    negative regulation of epithelial cell proliferation GO:0050680 IEA
    cell fate commitment GO:0045165 IBA
    positive regulation of cell proliferation GO:0008284 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA
    cellular response to retinoic acid GO:0071300 ISS
    positive regulation of epithelial cell differentiation GO:0030858 IEA
    positive regulation of G2/M transition of mitotic cell cycle GO:0010971 IEA
    positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 IEA
    regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 IEA
    bone trabecula formation GO:0060346 IEA
    positive regulation of canonical Wnt signaling pathway GO:0090263 IEA
    cell cycle arrest GO:0007050 IEA
    positive regulation of bone mineralization GO:0030501 IEA
    neuron differentiation GO:0030182 ISS
    Wnt signaling pathway GO:0016055 IMP
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 NAS
    proteinaceous extracellular matrix GO:0005578 IEA
 Experiment description of studies that identified WNT10B in exosomes
1
Experiment ID 193
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
PHB
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for WNT10B
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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