Gene description for WNT10B
Gene name wingless-type MMTV integration site family, member 10B
Gene symbol WNT10B
Other names/aliases SHFM6
WNT-12
Species Homo sapiens
 Database cross references - WNT10B
ExoCarta ExoCarta_7480
Vesiclepedia VP_7480
Entrez Gene 7480
HGNC 12775
MIM 601906
UniProt O00744  
 WNT10B identified in sEVs derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for WNT10B
Molecular Function
    frizzled binding GO:0005109 IBA
    cytokine activity GO:0005125 IBA
    protein binding GO:0005515 IPI
    receptor ligand activity GO:0048018 IC
Biological Process
    G2/M transition of mitotic cell cycle GO:0000086 IEA
    negative regulation of transcription by RNA polymerase II GO:0000122 IEA
    osteoblast differentiation GO:0001649 IEA
    chondrocyte differentiation GO:0002062 IEP
    transcription by RNA polymerase II GO:0006366 IEA
    lipid metabolic process GO:0006629 IEA
    smoothened signaling pathway GO:0007224 IEA
    positive regulation of G2/M transition of mitotic cell cycle GO:0010971 IEA
    myoblast differentiation involved in skeletal muscle regeneration GO:0014835 IEA
    neuron differentiation GO:0030182 IBA
    neuron differentiation GO:0030182 ISS
    T cell differentiation GO:0030217 IEA
    positive regulation of bone mineralization GO:0030501 IEA
    epithelial cell differentiation GO:0030855 IEA
    positive regulation of epithelial cell differentiation GO:0030858 IEA
    regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 IEA
    positive regulation of apoptotic process GO:0043065 IMP
    cell fate commitment GO:0045165 IBA
    fat cell differentiation GO:0045444 IEA
    positive regulation of T cell differentiation GO:0045582 IEA
    negative regulation of fat cell differentiation GO:0045599 IDA
    positive regulation of osteoblast differentiation GO:0045669 IEA
    positive regulation of RNA polymerase II transcription preinitiation complex assembly GO:0045899 IEA
    myoblast development GO:0048627 IEA
    regulation of skeletal muscle tissue development GO:0048641 IEA
    skeletal muscle fiber development GO:0048741 IEA
    negative regulation of epithelial cell proliferation GO:0050680 IEA
    protein stabilization GO:0050821 IDA
    sensory perception of taste GO:0050909 IEA
    positive regulation of timing of anagen GO:0051885 IEA
    canonical Wnt signaling pathway GO:0060070 IBA
    canonical Wnt signaling pathway GO:0060070 IDA
    bone trabecula formation GO:0060346 IEA
    fungiform papilla development GO:0061196 IEA
    cellular response to retinoic acid GO:0071300 ISS
    cellular response to cAMP GO:0071320 IEA
    cellular response to parathyroid hormone stimulus GO:0071374 IEA
    hematopoietic stem cell proliferation GO:0071425 IDA
    positive regulation of canonical Wnt signaling pathway GO:0090263 IEA
    negative regulation of cold-induced thermogenesis GO:0120163 ISS
    positive regulation of hematopoietic stem cell proliferation GO:1902035 IEA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 NAS
 Experiment description of studies that identified WNT10B in sEVs
1
Experiment ID 193
MISEV standards
EM
Biophysical techniques
CD63|CD9
Enriched markers
PHB
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for WNT10B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SIL1 64374
Affinity Capture-MS Homo sapiens
2 COL6A2 1292
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 DNAJC3 5611
Affinity Capture-MS Homo sapiens
4 FBXO2 26232
Affinity Capture-MS Homo sapiens
5 CLEC12B  
Affinity Capture-MS Homo sapiens
6 PDGFRA 5156
Affinity Capture-MS Homo sapiens
7 PPP6R3 55291
Affinity Capture-MS Homo sapiens
8 HSPA5 3309
Affinity Capture-MS Homo sapiens
9 SKP1 6500
Affinity Capture-MS Homo sapiens
10 MKRN2 23609
Affinity Capture-RNA Homo sapiens
11 SREBF2 6721
Positive Genetic Homo sapiens
12 OIT3 170392
Affinity Capture-MS Homo sapiens
13 PPP2R2D 55844
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 JMJD8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 LRP5 4041
Affinity Capture-MS Homo sapiens
16 NEU1 4758
Affinity Capture-MS Homo sapiens
17 LRP6 4040
Affinity Capture-MS Homo sapiens
18 PPP6R2 9701
Affinity Capture-MS Homo sapiens
19 NOTCH2 4853
Affinity Capture-MS Homo sapiens
20 NDUFA2 4695
Affinity Capture-MS Homo sapiens
21 FSTL1 11167
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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