Gene description for HYAL2
Gene name	hyaluronoglucosaminidase 2
Gene symbol	HYAL2
Other names/aliases	LUCA2
Species	Homo sapiens
Database cross references - HYAL2
ExoCarta	ExoCarta_8692
Entrez Gene	8692
HGNC	5321
MIM	603551
UniProt	Q12891
HYAL2 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927

Gene ontology annotations for HYAL2

Molecular Function     transforming growth factor beta binding GO:0050431 ISS     hyaluronoglucuronidase activity GO:0033906 IDA     enzyme binding GO:0019899 IPI     receptor signaling protein tyrosine kinase inhibitor activity GO:0030294 IDA     virus receptor activity GO:0001618 IDA     hyalurononglucosaminidase activity GO:0004415 TAS     protein binding GO:0005515 IPI     receptor tyrosine kinase binding GO:0030971 IPI     hyaluronic acid binding GO:0005540 IDA Biological Process     cellular response to UV-B GO:0071493 IDA     viral entry into host cell GO:0046718 ISS     glycosaminoglycan catabolic process GO:0006027 IDA     response to antibiotic GO:0046677 IEP     hematopoietic progenitor cell differentiation GO:0002244 IEA     cellular response to tumor necrosis factor GO:0071356 IEP     hyaluronan catabolic process GO:0030214 TAS     negative regulation of protein tyrosine kinase activity GO:0061099 IDA     negative regulation of protein kinase B signaling GO:0051898 IDA     negative regulation of fibroblast migration GO:0010764 IDA     kidney development GO:0001822 ISS     monocyte activation GO:0042117 IDA     cellular response to transforming growth factor beta stimulus GO:0071560 IDA     cellular response to interleukin-1 GO:0071347 IDA     glycosaminoglycan metabolic process GO:0030203 TAS     skeletal system morphogenesis GO:0048705 IEA     transformation of host cell by virus GO:0019087 ISS     hyaluronan metabolic process GO:0030212 TAS     response to reactive oxygen species GO:0000302 IDA     positive regulation of protein import into nucleus GO:0042307 ISS     multicellular organismal aging GO:0010259 IEA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISS     fusion of virus membrane with host plasma membrane GO:0019064 IDA     defense response to virus GO:0051607 IEA     positive regulation of inflammatory response GO:0050729 IDA     small molecule metabolic process GO:0044281 TAS     negative regulation of MAP kinase activity GO:0043407 IDA     response to virus GO:0009615 IDA     positive regulation of extrinsic apoptotic signaling pathway GO:2001238 ISS     positive regulation of interleukin-8 secretion GO:2000484 IDA     positive regulation of interleukin-6 secretion GO:2000778 IDA     positive regulation of urine volume GO:0035810 ISS     multicellular organismal iron ion homeostasis GO:0060586 IEA     renal water absorption GO:0070295 ISS     negative regulation of cell growth GO:0030308 IDA     cartilage development GO:0051216 IEP     cellular response to fibroblast growth factor stimulus GO:0044344 IDA     carbohydrate metabolic process GO:0005975 TAS Subcellular Localization     plasma membrane GO:0005886 TAS     anchored component of external side of plasma membrane GO:0031362 IDA     Golgi membrane GO:0000139 ISS     cytoplasm GO:0005737 IDA     RNA polymerase II transcription factor complex GO:0090575 ISS     perinuclear region of cytoplasm GO:0048471 IDA     endoplasmic reticulum GO:0005783 NAS     microvillus GO:0005902 IDA     endocytic vesicle GO:0030139 IDA     membrane raft GO:0045121 IDA     lysosome GO:0005764 IDA     cytoplasmic membrane-bounded vesicle GO:0016023 IDA     cell surface GO:0009986 ISS     cytoplasmic vesicle GO:0031410 IDA     apical plasma membrane GO:0016324 IDA     anchored component of plasma membrane GO:0046658 IDA     cytosol GO:0005829 IDA