Gene description for SLC39A5
Gene name solute carrier family 39 (zinc transporter), member 5
Gene symbol SLC39A5
Other names/aliases LZT-Hs7
MYP24
ZIP5
Species Homo sapiens
 Database cross references - SLC39A5
ExoCarta ExoCarta_283375
Entrez Gene 283375
HGNC 20502
MIM 608730
UniProt Q6ZMH5  
 SLC39A5 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for SLC39A5
Molecular Function
    metal ion transmembrane transporter activity GO:0046873 IEA
    molecular_function GO:0003674 ND
Biological Process
    neural precursor cell proliferation GO:0061351 ISS
    cellular response to zinc ion starvation GO:0034224 IEA
    BMP signaling pathway GO:0030509 IMP
    zinc II ion transport GO:0006829 IEA
    G1 to G0 transition involved in cell differentiation GO:0070315 ISS
    positive regulation of mRNA splicing, via spliceosome GO:0048026 IEA
    eye development GO:0001654 IMP
    transmembrane transport GO:0055085 TAS
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    integral component of membrane GO:0016021 IEA
    basolateral plasma membrane GO:0016323 IEA
 Experiment description of studies that identified SLC39A5 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SLC39A5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SLC39A5 is involved
PathwayEvidenceSource
Zinc influx into cells by the SLC39 gene family TAS Reactome





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