Gene description for SLC39A5
Gene name solute carrier family 39 (zinc transporter), member 5
Gene symbol SLC39A5
Other names/aliases LZT-Hs7
MYP24
ZIP5
Species Homo sapiens
 Database cross references - SLC39A5
ExoCarta ExoCarta_283375
Vesiclepedia VP_283375
Entrez Gene 283375
HGNC 20502
MIM 608730
UniProt Q6ZMH5  
 SLC39A5 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for SLC39A5
Molecular Function
    zinc ion transmembrane transporter activity GO:0005385 IBA
    zinc ion transmembrane transporter activity GO:0005385 ISS
    monoatomic cation:bicarbonate symporter activity GO:0140410 IBA
Biological Process
    eye development GO:0001654 IMP
    zinc ion transport GO:0006829 ISS
    bicarbonate transport GO:0015701 IEA
    intracellular monoatomic cation homeostasis GO:0030003 IBA
    BMP signaling pathway GO:0030509 IMP
    cellular response to zinc ion starvation GO:0034224 IEA
    positive regulation of mRNA splicing, via spliceosome GO:0048026 IEA
    neural precursor cell proliferation GO:0061351 ISS
    G1 to G0 transition involved in cell differentiation GO:0070315 ISS
    zinc ion transmembrane transport GO:0071577 ISS
    zinc ion import across plasma membrane GO:0071578 IBA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    basolateral plasma membrane GO:0016323 ISS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified SLC39A5 in exosomes
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SLC39A5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ULBP3 79465
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 LRFN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 CYSTM1 84418
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 GPR89A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 CTAGE5 4253
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 C1GALT1C1 29071
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 FAM171A2 284069
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 GOLPH3 64083
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 SLC39A6 25800
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 ULBP2 80328
Affinity Capture-MS Homo sapiens
11 TMEM223  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 EXTL3 2137
Affinity Capture-MS Homo sapiens
13 RYK 6259
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 LRFN3  
Affinity Capture-MS Homo sapiens
15 EXTL2 2135
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 EFNB1 1947
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 ACP2 53
Affinity Capture-MS Homo sapiens
18 PTPN2 5771
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 CHSY1 22856
Affinity Capture-MS Homo sapiens
20 TMEM246 84302
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 NAT14 57106
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 C3orf33  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 LRP10 26020
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 SCARF2 91179
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 SLC35B2 347734
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 CDON  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 GOLPH3L 55204
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 CHPT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 EXT1 2131
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 AXDND1  
Affinity Capture-MS Homo sapiens
31 PTPRS 5802
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 SLC39A10 57181
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 SLC25A51  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 ULBP1  
Affinity Capture-MS Homo sapiens
35 MIA3 375056
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 HYAL2 8692
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 FGFR4 2264
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 METTL9 51108
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 GP1BB 2812
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 TMEM55A 55529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 ERMP1 79956
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 HLA-A 3105
Affinity Capture-MS Homo sapiens
43 ARL10  
Affinity Capture-MS Homo sapiens
44 MRS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 SLC22A18 5002
Affinity Capture-MS Homo sapiens
46 ABHD14A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 TNFSF9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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