Gene description for CLPTM1
Gene name cleft lip and palate associated transmembrane protein 1
Gene symbol CLPTM1
Other names/aliases -
Species Homo sapiens
 Database cross references - CLPTM1
ExoCarta ExoCarta_1209
Vesiclepedia VP_1209
Entrez Gene 1209
HGNC 2087
MIM 604783
UniProt O96005  
 CLPTM1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for CLPTM1
Molecular Function
    protein binding GO:0005515 IPI
    GABA receptor binding GO:0050811 IEA
Biological Process
    cell differentiation GO:0030154 IEA
    regulation of T cell differentiation in thymus GO:0033081 ISS
    regulation of postsynaptic membrane neurotransmitter receptor levels GO:0099072 IEA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 ISS
    endomembrane system GO:0012505 IBA
    membrane GO:0016020 HDA
    membrane GO:0016020 IBA
    GABA-ergic synapse GO:0098982 IEA
 Experiment description of studies that identified CLPTM1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for CLPTM1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HSD17B11 51170
Proximity Label-MS Homo sapiens
2 ISG15 9636
Affinity Capture-MS Homo sapiens
3 Sgol2  
Affinity Capture-MS Mus musculus
4 RNASEH2B  
Affinity Capture-MS Homo sapiens
5 KLK15  
Affinity Capture-MS Homo sapiens
6 COIL  
Proximity Label-MS Homo sapiens
7 METTL7A 25840
Proximity Label-MS Homo sapiens
8 MFNG  
Affinity Capture-MS Homo sapiens
9 CCR4 1233
Two-hybrid Homo sapiens
10 CFC1  
Affinity Capture-MS Homo sapiens
11 CCR2  
Two-hybrid Homo sapiens
12 SYVN1 84447
Affinity Capture-MS Homo sapiens
13 LRRN4CL 221091
Affinity Capture-MS Homo sapiens
14 TM2D3  
Affinity Capture-MS Homo sapiens
15 PGK1 5230
Affinity Capture-MS Homo sapiens
16 ASIC1  
Affinity Capture-MS Homo sapiens
17 SSR1 6745
Proximity Label-MS Homo sapiens
18 CCDC47 57003
Affinity Capture-MS Homo sapiens
19 F2RL1  
Two-hybrid Homo sapiens
20 ELSPBP1  
Affinity Capture-MS Homo sapiens
21 BTNL2  
Affinity Capture-MS Homo sapiens
22 TMEM106A  
Affinity Capture-MS Homo sapiens
23 FZD7 8324
Two-hybrid Homo sapiens
24 FGFR1 2260
Affinity Capture-MS Homo sapiens
25 CLGN 1047
Affinity Capture-MS Homo sapiens
26 GPR17 2840
Affinity Capture-MS Homo sapiens
27 RBPJ 3516
Affinity Capture-MS Homo sapiens
28 HLA-G 3135
Affinity Capture-MS Homo sapiens
29 LMAN1 3998
Affinity Capture-MS Homo sapiens
30 KLRC4  
Affinity Capture-MS Homo sapiens
31 RB1CC1 9821
Affinity Capture-MS Homo sapiens
32 PARK2  
Affinity Capture-MS Homo sapiens
33 UBAC2 337867
Affinity Capture-MS Homo sapiens
34 SDF2L1 23753
Affinity Capture-MS Homo sapiens
35 ODF4  
Affinity Capture-MS Homo sapiens
36 NTRK1 4914
Affinity Capture-MS Homo sapiens
37 SIRPD  
Affinity Capture-MS Homo sapiens
38 DHH  
Affinity Capture-MS Homo sapiens
39 TCTN2  
Affinity Capture-MS Homo sapiens
40 LYPD1  
Affinity Capture-MS Homo sapiens
41 RPN1 6184
Proximity Label-MS Homo sapiens
42 SEC62 7095
Proximity Label-MS Homo sapiens
43 SEC61B 10952
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 HTR3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 P2RY2 5029
Affinity Capture-MS Homo sapiens
46 C4orf32  
Affinity Capture-MS Homo sapiens
47 RPN2 6185
Proximity Label-MS Homo sapiens
48 CANX 821
Affinity Capture-MS Homo sapiens
49 LRRC59 55379
Proximity Label-MS Homo sapiens
50 GPR108 56927
Affinity Capture-MS Homo sapiens
51 GGH 8836
Affinity Capture-MS Homo sapiens
52 TMEM255B  
Affinity Capture-MS Homo sapiens
53 ERGIC3 51614
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 PRG2  
Affinity Capture-MS Homo sapiens
55 HSD3B7 80270
Proximity Label-MS Homo sapiens
56 STIM1 6786
Proximity Label-MS Homo sapiens
57 DNAJB9 4189
Affinity Capture-MS Homo sapiens
58 SLC10A2  
Affinity Capture-MS Homo sapiens
59 RPA3 6119
Proximity Label-MS Homo sapiens
60 ATP2A1 487
Proximity Label-MS Homo sapiens
61 FBXO2 26232
Affinity Capture-MS Homo sapiens
62 Cdca8  
Affinity Capture-MS Mus musculus
63 GXYLT1 283464
Affinity Capture-MS Homo sapiens
64 EBAG9 9166
Proximity Label-MS Homo sapiens
65 ENTPD2 954
Affinity Capture-MS Homo sapiens
66 SCNN1D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 AP3S1 1176
Affinity Capture-MS Homo sapiens
68 CLPP 8192
Proximity Label-MS Homo sapiens
69 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
70 TP53 7157
Affinity Capture-MS Homo sapiens
71 LINC00839  
Protein-RNA Homo sapiens
72 PDIA4 9601
Proximity Label-MS Homo sapiens
73 ASIC4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 TMPRSS12  
Affinity Capture-MS Homo sapiens
75 CD1A 909
Affinity Capture-MS Homo sapiens
76 UNC93B1 81622
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
77 Shoc2  
Affinity Capture-MS Mus musculus
78 ICT1 3396
Co-fractionation Homo sapiens
79 NCR3  
Affinity Capture-MS Homo sapiens
80 DDX58 23586
Affinity Capture-RNA Homo sapiens
81 APOM 55937
Affinity Capture-MS Homo sapiens
82 SFTPC  
Affinity Capture-MS Homo sapiens
83 SRD5A2  
Affinity Capture-MS Homo sapiens
84 ERGIC2 51290
Proximity Label-MS Homo sapiens
85 OR5M11  
Affinity Capture-MS Homo sapiens
86 HM13 81502
Affinity Capture-MS Homo sapiens
87 PARD6B 84612
Affinity Capture-MS Homo sapiens
88 SPPL2B 56928
Affinity Capture-MS Homo sapiens
89 NCEH1 57552
Affinity Capture-MS Homo sapiens
90 TMC4  
Affinity Capture-MS Homo sapiens
91 SERBP1 26135
Affinity Capture-MS Homo sapiens
92 STT3B 201595
Affinity Capture-MS Homo sapiens
93 DNAJC1 64215
Proximity Label-MS Homo sapiens
94 P2RX2  
Affinity Capture-MS Homo sapiens
95 CCR6  
Affinity Capture-MS Homo sapiens
96 CKAP4 10970
Proximity Label-MS Homo sapiens
97 RPA2 6118
Proximity Label-MS Homo sapiens
98 CCR1  
Affinity Capture-MS Homo sapiens
99 DERL1 79139
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CLPTM1 is involved
No pathways found





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