Gene description for SEMA6B
Gene name sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
Gene symbol SEMA6B
Other names/aliases SEM-SEMA-Y
SEMA-VIB
SEMAN
semaZ
Species Homo sapiens
 Database cross references - SEMA6B
ExoCarta ExoCarta_10501
Vesiclepedia VP_10501
Entrez Gene 10501
HGNC 10739
MIM 608873
UniProt Q9H3T3  
 SEMA6B identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for SEMA6B
Molecular Function
    protein binding GO:0005515 IPI
    semaphorin receptor binding GO:0030215 IBA
    chemorepellent activity GO:0045499 IBA
Biological Process
    neural crest cell migration GO:0001755 IBA
    axon guidance GO:0007411 IBA
    axon guidance GO:0007411 ISS
    central nervous system development GO:0007417 IMP
    hippocampus development GO:0021766 ISS
    positive regulation of cell migration GO:0030335 IBA
    semaphorin-plexin signaling pathway GO:0071526 IBA
Subcellular Localization
    plasma membrane GO:0005886 IBA
 Experiment description of studies that identified SEMA6B in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SEMA6B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LY86  
Affinity Capture-MS Homo sapiens
2 NRG1 3084
Affinity Capture-MS Homo sapiens
3 FMOD 2331
Affinity Capture-MS Homo sapiens
4 BTNL2  
Affinity Capture-MS Homo sapiens
5 TMEM106A  
Affinity Capture-MS Homo sapiens
6 KLK15  
Affinity Capture-MS Homo sapiens
7 LCN6  
Affinity Capture-MS Homo sapiens
8 TMEM87A 25963
Affinity Capture-MS Homo sapiens
9 HLA-G 3135
Affinity Capture-MS Homo sapiens
10 HLA-E 3133
Affinity Capture-MS Homo sapiens
11 HLA-DRA 3122
Affinity Capture-MS Homo sapiens
12 ASIC4  
Affinity Capture-MS Homo sapiens
13 PDGFRA 5156
Affinity Capture-MS Homo sapiens
14 PRG2  
Affinity Capture-MS Homo sapiens
15 MFAP4 4239
Affinity Capture-MS Homo sapiens
16 CBLN4  
Affinity Capture-MS Homo sapiens
17 KLRD1  
Affinity Capture-MS Homo sapiens
18 GAA 2548
Affinity Capture-MS Homo sapiens
19 CLEC4C  
Affinity Capture-MS Homo sapiens
20 IL5RA  
Affinity Capture-MS Homo sapiens
21 SFTPC  
Affinity Capture-MS Homo sapiens
22 HLA-DQA1 3117
Affinity Capture-MS Homo sapiens
23 C1QB 713
Affinity Capture-MS Homo sapiens
24 SDF2L1 23753
Affinity Capture-MS Homo sapiens
25 KLK3  
Affinity Capture-MS Homo sapiens
26 FBXO2 26232
Affinity Capture-MS Homo sapiens
27 CRISP2  
Affinity Capture-MS Homo sapiens
28 DNAJB9 4189
Affinity Capture-MS Homo sapiens
29 GXYLT1 283464
Affinity Capture-MS Homo sapiens
30 SLURP1  
Affinity Capture-MS Homo sapiens
31 CLEC2B  
Affinity Capture-MS Homo sapiens
32 DNASE1L1 1774
Affinity Capture-MS Homo sapiens
33 CST9L  
Affinity Capture-MS Homo sapiens
34 ISLR 3671
Affinity Capture-MS Homo sapiens
35 DDX58 23586
Affinity Capture-RNA Homo sapiens
36 PTCH1  
Affinity Capture-MS Homo sapiens
37 HLA-DPA1  
Affinity Capture-MS Homo sapiens
38 LYPD4  
Affinity Capture-MS Homo sapiens
39 DNAJB11 51726
Affinity Capture-MS Homo sapiens
40 PCDHB3  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SEMA6B is involved
No pathways found





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