Gene description for EDEM3
Gene name ER degradation enhancer, mannosidase alpha-like 3
Gene symbol EDEM3
Other names/aliases C1orf22
Species Homo sapiens
 Database cross references - EDEM3
ExoCarta ExoCarta_80267
Vesiclepedia VP_80267
Entrez Gene 80267
HGNC 16787
MIM 610214
UniProt Q9BZQ6  
 EDEM3 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for EDEM3
Molecular Function
    mannosyl-oligosaccharide 1,2-alpha-mannosidase activity GO:0004571 IBA
    mannosyl-oligosaccharide 1,2-alpha-mannosidase activity GO:0004571 IMP
    mannosyl-oligosaccharide 1,2-alpha-mannosidase activity GO:0004571 TAS
    calcium ion binding GO:0005509 IEA
Biological Process
    carbohydrate metabolic process GO:0005975 IEA
    mannoprotein catabolic process GO:0006058 IBA
    mannoprotein catabolic process GO:0006058 IMP
    protein glycosylation GO:0006486 IEA
    endoplasmic reticulum unfolded protein response GO:0030968 IBA
    ERAD pathway GO:0036503 IMP
    ubiquitin-dependent glycoprotein ERAD pathway GO:0097466 IBA
    endoplasmic reticulum mannose trimming GO:1904380 IEA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum lumen GO:0005788 IEA
    membrane GO:0016020 IEA
    endoplasmic reticulum quality control compartment GO:0044322 TAS
 Experiment description of studies that identified EDEM3 in exosomes
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for EDEM3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LYZL2  
Affinity Capture-MS Homo sapiens
2 UPK2 7379
Affinity Capture-MS Homo sapiens
3 DEFA1 1667
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 GPIHBP1  
Affinity Capture-MS Homo sapiens
5 ELSPBP1  
Affinity Capture-MS Homo sapiens
6 CA6 765
Affinity Capture-MS Homo sapiens
7 KLK15  
Affinity Capture-MS Homo sapiens
8 CEACAM8 1088
Affinity Capture-MS Homo sapiens
9 LGI1  
Affinity Capture-MS Homo sapiens
10 Zwint  
Affinity Capture-MS Mus musculus
11 TMEM87A 25963
Affinity Capture-MS Homo sapiens
12 GP9 2815
Affinity Capture-MS Homo sapiens
13 ALOXE3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 FPR1  
Affinity Capture-MS Homo sapiens
15 C7orf34  
Affinity Capture-MS Homo sapiens
16 CHST8 64377
Affinity Capture-MS Homo sapiens
17 GGH 8836
Affinity Capture-MS Homo sapiens
18 TRIM66  
Affinity Capture-MS Homo sapiens
19 CD70 970
Affinity Capture-MS Homo sapiens
20 CFC1  
Affinity Capture-MS Homo sapiens
21 EDEM1  
Affinity Capture-MS Homo sapiens
22 PRG2  
Affinity Capture-MS Homo sapiens
23 MFAP4 4239
Affinity Capture-MS Homo sapiens
24 PI15  
Affinity Capture-MS Homo sapiens
25 TRIM33 51592
Affinity Capture-MS Homo sapiens
26 CBLN4  
Affinity Capture-MS Homo sapiens
27 LY9 4063
Affinity Capture-MS Homo sapiens
28 FBXO6 26270
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 OS9 10956
Affinity Capture-MS Homo sapiens
30 P2RY8  
Affinity Capture-MS Homo sapiens
31 RIPK4  
Affinity Capture-MS Homo sapiens
32 LRPPRC 10128
Affinity Capture-MS Homo sapiens
33 BTNL2  
Affinity Capture-MS Homo sapiens
34 ANGPTL7 10218
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 TM2D3  
Affinity Capture-MS Homo sapiens
36 SHH  
Affinity Capture-Western Homo sapiens
37 PLD3 23646
Affinity Capture-MS Homo sapiens
38 PBXIP1 57326
Affinity Capture-MS Homo sapiens
39 SDF2L1 23753
Affinity Capture-MS Homo sapiens
40 FIBIN  
Affinity Capture-MS Homo sapiens
41 NTRK1 4914
Affinity Capture-MS Homo sapiens
42 GPR45  
Affinity Capture-MS Homo sapiens
43 NCR3  
Affinity Capture-MS Homo sapiens
44 GPR182  
Affinity Capture-MS Homo sapiens
45 DNAJB9 4189
Affinity Capture-MS Homo sapiens
46 GXYLT1 283464
Affinity Capture-MS Homo sapiens
47 CDHR4  
Affinity Capture-MS Homo sapiens
48 SEL1L 6400
Affinity Capture-Western Homo sapiens
49 CLEC2B  
Affinity Capture-MS Homo sapiens
50 P2RY10  
Affinity Capture-MS Homo sapiens
51 ISLR 3671
Affinity Capture-MS Homo sapiens
52 IL5RA  
Affinity Capture-MS Homo sapiens
53 TRAV20  
Affinity Capture-MS Homo sapiens
54 KIAA1644  
Affinity Capture-MS Homo sapiens
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