Gene description for DCUN1D5
Gene name DCN1, defective in cullin neddylation 1, domain containing 5
Gene symbol DCUN1D5
Other names/aliases -
Species Homo sapiens
 Database cross references - DCUN1D5
ExoCarta ExoCarta_84259
Vesiclepedia VP_84259
Entrez Gene 84259
HGNC 28409
UniProt Q9BTE7  
 DCUN1D5 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for DCUN1D5
Molecular Function
    protein binding GO:0005515 IPI
    ubiquitin conjugating enzyme binding GO:0031624 IBA
    ubiquitin-like protein binding GO:0032182 IBA
    cullin family protein binding GO:0097602 IBA
    cullin family protein binding GO:0097602 IMP
Biological Process
    regulation of cell growth GO:0001558 IMP
    DNA damage response GO:0006974 IMP
    protein neddylation GO:0045116 IBA
    regulation of protein neddylation GO:2000434 IMP
    positive regulation of protein neddylation GO:2000436 IMP
Subcellular Localization
    ubiquitin ligase complex GO:0000151 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 IMP
    cytoplasm GO:0005737 IEA
    spindle GO:0005819 IDA
 Experiment description of studies that identified DCUN1D5 in exosomes
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for DCUN1D5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 GSX1  
Affinity Capture-MS Homo sapiens
3 UBE2F  
Reconstituted Complex Homo sapiens
4 GYPA  
Affinity Capture-MS Homo sapiens
5 LYPD3 27076
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 CYB5B 80777
Affinity Capture-MS Homo sapiens
7 FAM177A1 283635
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 CUL2 8453
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
9 GPR17 2840
Affinity Capture-MS Homo sapiens
10 TLN2 83660
Co-fractionation Homo sapiens
11 COX4I2 84701
Affinity Capture-MS Homo sapiens
12 SUB1 10923
Cross-Linking-MS (XL-MS) Homo sapiens
13 UBE2M 9040
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
14 KIAA1324 57535
Affinity Capture-MS Homo sapiens
15 CD70 970
Affinity Capture-MS Homo sapiens
16 TMEM206 55248
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 CUL5 8065
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
18 CUL3 8452
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
19 BRD2  
Affinity Capture-MS Homo sapiens
20 RBX1 9978
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
21 GTPBP10  
Co-fractionation Homo sapiens
22 TMEM213  
Affinity Capture-MS Homo sapiens
23 PTPN1 5770
Affinity Capture-MS Homo sapiens
24 METTL21B  
Affinity Capture-MS Homo sapiens
25 ACADVL 37
Affinity Capture-MS Homo sapiens
26 CUL1 8454
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
27 PNKD  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 RNF7  
Affinity Capture-MS Homo sapiens
29 ORMDL1 94101
Affinity Capture-MS Homo sapiens
30 CUL4B 8450
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
31 RCHY1  
Two-hybrid Homo sapiens
32 IFI27L1  
Affinity Capture-MS Homo sapiens
33 CAPZB 832
Affinity Capture-MS Homo sapiens
34 RPA3 6119
Proximity Label-MS Homo sapiens
35 KRTAP19-7  
Affinity Capture-MS Homo sapiens
36 PLEKHG4  
Two-hybrid Homo sapiens
37 FIS1 51024
Affinity Capture-MS Homo sapiens
38 C3orf18  
Affinity Capture-MS Homo sapiens
39 FOXL2  
Affinity Capture-MS Homo sapiens
40 HECW2  
Affinity Capture-MS Homo sapiens
41 FOXL1  
Affinity Capture-MS Homo sapiens
42 DDB1 1642
Affinity Capture-MS Homo sapiens
43 UBL7  
Co-fractionation Homo sapiens
44 RNF111 54778
Affinity Capture-MS Homo sapiens
45 TEAD2  
Affinity Capture-MS Homo sapiens
46 TGFA  
Affinity Capture-MS Homo sapiens
47 SERBP1 26135
Affinity Capture-MS Homo sapiens
48 SAC3D1  
Co-fractionation Homo sapiens
49 CYCS 54205
Affinity Capture-MS Homo sapiens
50 CAND1 55832
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
51 MAPK14 1432
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 HUS1  
Two-hybrid Homo sapiens
53 FXYD3 5349
Affinity Capture-MS Homo sapiens
54 JTB 10899
Affinity Capture-MS Homo sapiens
55 FGFR1OP2  
Affinity Capture-MS Homo sapiens
56 CHUK 1147
Biochemical Activity Homo sapiens
57 LNX1  
Two-hybrid Homo sapiens
58 CUL4A 8451
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
59 GNAI3 2773
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DCUN1D5 is involved
PathwayEvidenceSource
Metabolism of proteins TAS Reactome
Neddylation TAS Reactome
Post-translational protein modification TAS Reactome





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