Gene description for NDC1
Gene name NDC1 transmembrane nucleoporin
Gene symbol NDC1
Other names/aliases NET3
TMEM48
Species Homo sapiens
 Database cross references - NDC1
ExoCarta ExoCarta_55706
Vesiclepedia VP_55706
Entrez Gene 55706
HGNC 25525
MIM 610115
UniProt Q9BTX1  
 NDC1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for NDC1
Molecular Function
    structural constituent of nuclear pore GO:0017056 IMP
    protein-macromolecule adaptor activity GO:0030674 IBA
Biological Process
    nucleocytoplasmic transport GO:0006913 NAS
    nuclear pore organization GO:0006999 IBA
    homologous chromosome pairing at meiosis GO:0007129 IEA
    spermatogenesis GO:0007283 IEA
    protein transport GO:0015031 NAS
    mRNA transport GO:0051028 IEA
    nuclear pore complex assembly GO:0051292 IMP
    nuclear pore localization GO:0051664 IMP
Subcellular Localization
    nuclear envelope GO:0005635 IDA
    nuclear envelope GO:0005635 TAS
    nuclear pore GO:0005643 IDA
    nuclear pore GO:0005643 NAS
    cytoplasm GO:0005737 IEA
    plasma membrane GO:0005886 IDA
    actin cytoskeleton GO:0015629 IDA
    membrane GO:0016020 HDA
    nuclear membrane GO:0031965 IDA
    nuclear pore transmembrane ring GO:0070762 IBA
 Experiment description of studies that identified NDC1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NDC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HSD17B11 51170
Proximity Label-MS Homo sapiens
2 LYPD3 27076
Affinity Capture-MS Homo sapiens
3 METTL7A 25840
Proximity Label-MS Homo sapiens
4 LAMP3  
Proximity Label-MS Homo sapiens
5 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
6 SLC39A4 55630
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 GJA1 2697
Proximity Label-MS Homo sapiens
8 RPA2 6118
Proximity Label-MS Homo sapiens
9 KPNB1 3837
Affinity Capture-MS Homo sapiens
10 CTDNEP1 23399
Proximity Label-MS Homo sapiens
11 IGHM 3507
Affinity Capture-MS Homo sapiens
12 NUPL1 9818
Affinity Capture-MS Homo sapiens
13 MDFI  
Affinity Capture-MS Homo sapiens
14 TNFRSF8 943
Affinity Capture-MS Homo sapiens
15 GJD3  
Proximity Label-MS Homo sapiens
16 UBC 7316
Reconstituted Complex Homo sapiens
17 LAMP2 3920
Proximity Label-MS Homo sapiens
18 DNAJC25 548645
Proximity Label-MS Homo sapiens
19 COPE 11316
Affinity Capture-MS Homo sapiens
20 PTPN1 5770
Proximity Label-MS Homo sapiens
21 STX4 6810
Proximity Label-MS Homo sapiens
22 C9orf78 51759
Affinity Capture-MS Homo sapiens
23 B3GAT1  
Proximity Label-MS Homo sapiens
24 NUP153 9972
Affinity Capture-MS Homo sapiens
25 RAB3B 5865
Proximity Label-MS Homo sapiens
26 SSR1 6745
Proximity Label-MS Homo sapiens
27 OBSL1 23363
Affinity Capture-MS Homo sapiens
28 JTB 10899
Affinity Capture-MS Homo sapiens
29 C3orf52  
Affinity Capture-MS Homo sapiens
30 TTYH1  
Affinity Capture-MS Homo sapiens
31 STX6 10228
Proximity Label-MS Homo sapiens
32 TMEM192 201931
Affinity Capture-MS Homo sapiens
33 ABHD14A  
Affinity Capture-MS Homo sapiens
34 SLC25A46 91137
Proximity Label-MS Homo sapiens
35 CANX 821
Affinity Capture-MS Homo sapiens
36 PANX1 24145
Proximity Label-MS Homo sapiens
37 RAB35 11021
Proximity Label-MS Homo sapiens
38 EBAG9 9166
Proximity Label-MS Homo sapiens
39 MARCKS 4082
Proximity Label-MS Homo sapiens
40 LMAN1 3998
Proximity Label-MS Homo sapiens
41 NUP155 9631
Proximity Label-MS Homo sapiens
42 KIAA1715 80856
Proximity Label-MS Homo sapiens
43 PXMP2  
Proximity Label-MS Homo sapiens
44 RAB5A 5868
Proximity Label-MS Homo sapiens
45 PIGH  
Affinity Capture-MS Homo sapiens
46 LMNB1 4001
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 Rcc1  
Affinity Capture-MS Mus musculus
48 EMD 2010
Proximity Label-MS Homo sapiens
49 CXADR 1525
Proximity Label-MS Homo sapiens
50 EMP3 2014
Affinity Capture-MS Homo sapiens
51 SCAP  
Affinity Capture-MS Homo sapiens
52 MAPRE1 22919
Affinity Capture-MS Homo sapiens
53 RAB4A 5867
Proximity Label-MS Homo sapiens
54 UBE2I 7329
Affinity Capture-MS Homo sapiens
55 PCDHGC4  
Affinity Capture-MS Homo sapiens
56 RAN 5901
Affinity Capture-MS Homo sapiens
57 GDPD5 81544
Affinity Capture-MS Homo sapiens
58 LRRTM1 347730
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 DTX2 113878
Proximity Label-MS Homo sapiens
60 IL27RA 9466
Affinity Capture-MS Homo sapiens
61 IPPK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 DHFRL1  
Proximity Label-MS Homo sapiens
63 UPK1A 11045
Affinity Capture-MS Homo sapiens
64 Ube2i  
Affinity Capture-MS Mus musculus
65 RHOT2 89941
Proximity Label-MS Homo sapiens
66 ELOVL5 60481
Proximity Label-MS Homo sapiens
67 SEC61B 10952
Proximity Label-MS Homo sapiens
68 Nup155  
Affinity Capture-MS Mus musculus
69 SLC7A1 6541
Affinity Capture-MS Homo sapiens
70 CRELD1 78987
Affinity Capture-MS Homo sapiens
71 REEP5 7905
Proximity Label-MS Homo sapiens
72 SEC63 11231
Proximity Label-MS Homo sapiens
73 APLNR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 CXCR4 7852
Affinity Capture-MS Homo sapiens
75 RPN2 6185
Proximity Label-MS Homo sapiens
76 Nup98  
Affinity Capture-MS Mus musculus
77 RAB7A 7879
Proximity Label-MS Homo sapiens
78 LRRC59 55379
Proximity Label-MS Homo sapiens
79 EGLN3  
Affinity Capture-MS Homo sapiens
80 LAMP1 3916
Proximity Label-MS Homo sapiens
81 Bmpr1a  
Affinity Capture-MS Mus musculus
82 ERGIC3 51614
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 BCAP31 10134
Proximity Label-MS Homo sapiens
84 HSD3B7 80270
Proximity Label-MS Homo sapiens
85 GPR12  
Affinity Capture-MS Homo sapiens
86 STIM1 6786
Proximity Label-MS Homo sapiens
87 FKBP8 23770
Proximity Label-MS Homo sapiens
88 ARF6 382
Proximity Label-MS Homo sapiens
89 AAAS 8086
Affinity Capture-MS Homo sapiens
90 DPEP1 1800
Affinity Capture-MS Homo sapiens
91 YIPF5 81555
Affinity Capture-MS Homo sapiens
92 LPAR1 1902
Affinity Capture-MS Homo sapiens
93 TMEM169  
Affinity Capture-MS Homo sapiens
94 SAAL1 113174
Affinity Capture-MS Homo sapiens
95 Nup107  
Affinity Capture-MS Mus musculus
96 RPA3 6119
Proximity Label-MS Homo sapiens
97 ATP2A1 487
Proximity Label-MS Homo sapiens
98 CMTM5  
Affinity Capture-MS Homo sapiens
99 RAB9A 9367
Proximity Label-MS Homo sapiens
100 TMEM9 252839
Affinity Capture-MS Homo sapiens
101 COPB2 9276
Affinity Capture-MS Homo sapiens
102 RPN1 6184
Proximity Label-MS Homo sapiens
103 RHOB 388
Proximity Label-MS Homo sapiens
104 SEH1L 81929
Affinity Capture-MS Homo sapiens
105 CYP2C9  
Proximity Label-MS Homo sapiens
106 LMNA 4000
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
107 AKAP1 8165
Proximity Label-MS Homo sapiens
108 CCDC8  
Affinity Capture-MS Homo sapiens
109 CLPP 8192
Proximity Label-MS Homo sapiens
110 RNF43  
Proximity Label-MS Homo sapiens
111 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
112 TSPAN5 10098
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 SCGB2A1 4246
Affinity Capture-MS Homo sapiens
114 Ndc1  
Affinity Capture-MS Mus musculus
115 C3AR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 COPA 1314
Affinity Capture-MS Homo sapiens
117 CLCA2  
Affinity Capture-MS Homo sapiens
118 MEN1 4221
Affinity Capture-MS Homo sapiens
119 OPALIN  
Affinity Capture-MS Homo sapiens
120 TSPAN15 23555
Affinity Capture-MS Homo sapiens
121 NUP35 129401
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
122 ERGIC1 57222
Proximity Label-MS Homo sapiens
123 ERGIC2 51290
Proximity Label-MS Homo sapiens
124 NUP107 57122
Affinity Capture-MS Homo sapiens
125 LRRC55  
Affinity Capture-MS Homo sapiens
126 RAB2A 5862
Proximity Label-MS Homo sapiens
127 SEC62 7095
Proximity Label-MS Homo sapiens
128 ZNRF4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
129 CEP135  
Proximity Label-MS Homo sapiens
130 SLC25A51  
Proximity Label-MS Homo sapiens
131 RAB11A 8766
Proximity Label-MS Homo sapiens
132 RPUSD3  
Proximity Label-MS Homo sapiens
133 Ranbp2  
Affinity Capture-MS Mus musculus
134 EPHA2 1969
Proximity Label-MS Homo sapiens
135 SERBP1 26135
Affinity Capture-MS Homo sapiens
136 DNAJC1 64215
Proximity Label-MS Homo sapiens
137 KRAS 3845
Synthetic Lethality Homo sapiens
Proximity Label-MS Homo sapiens
138 RAB5C 5878
Proximity Label-MS Homo sapiens
139 HTR1B  
Affinity Capture-MS Homo sapiens
140 PCDH10 57575
Affinity Capture-MS Homo sapiens
141 CKAP4 10970
Proximity Label-MS Homo sapiens
142 SPINT2 10653
Affinity Capture-MS Homo sapiens
143 GNAI3 2773
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
144 DERL1 79139
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which NDC1 is involved
PathwayEvidenceSource
Antiviral mechanism by IFN-stimulated genes TAS Reactome
Cell Cycle TAS Reactome
Cell Cycle IEA Reactome
Cell Cycle, Mitotic TAS Reactome
Cell Cycle, Mitotic IEA Reactome
Cellular response to heat stress TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) TAS Reactome
Disease TAS Reactome
Disease IEA Reactome
Disorders of transmembrane transporters TAS Reactome
Export of Viral Ribonucleoproteins from Nucleus TAS Reactome
Gene expression (Transcription) TAS Reactome
Gene Silencing by RNA TAS Reactome
Glucose metabolism TAS Reactome
Glycolysis TAS Reactome
HCMV Early Events TAS Reactome
HCMV Infection TAS Reactome
HCMV Late Events TAS Reactome
HIV Infection IEA Reactome
HIV Infection TAS Reactome
HIV Life Cycle TAS Reactome
Host Interactions of HIV factors IEA Reactome
Host Interactions of HIV factors TAS Reactome
Immune System TAS Reactome
Infectious disease TAS Reactome
Infectious disease IEA Reactome
Influenza Infection TAS Reactome
Influenza Viral RNA Transcription and Replication TAS Reactome
Interactions of Rev with host cellular proteins IEA Reactome
Interactions of Rev with host cellular proteins TAS Reactome
Interactions of Vpr with host cellular proteins TAS Reactome
Interferon Signaling TAS Reactome
ISG15 antiviral mechanism TAS Reactome
Late Phase of HIV Life Cycle TAS Reactome
M Phase TAS Reactome
M Phase IEA Reactome
Metabolism TAS Reactome
Metabolism of carbohydrates TAS Reactome
Metabolism of non-coding RNA TAS Reactome
Metabolism of proteins TAS Reactome
Metabolism of proteins IEA Reactome
Metabolism of RNA TAS Reactome
Mitotic Anaphase TAS Reactome
Mitotic Anaphase IEA Reactome
Mitotic Metaphase and Anaphase TAS Reactome
Mitotic Metaphase and Anaphase IEA Reactome
Mitotic Prophase TAS Reactome
NEP/NS2 Interacts with the Cellular Export Machinery TAS Reactome
NS1 Mediated Effects on Host Pathways TAS Reactome
Nuclear Envelope (NE) Reassembly TAS Reactome
Nuclear Envelope (NE) Reassembly IEA Reactome
Nuclear Envelope Breakdown TAS Reactome
Nuclear import of Rev protein IEA Reactome
Nuclear Pore Complex (NPC) Disassembly TAS Reactome
Post-translational protein modification TAS Reactome
Post-translational protein modification IEA Reactome
Postmitotic nuclear pore complex (NPC) reformation TAS Reactome
Postmitotic nuclear pore complex (NPC) reformation IEA Reactome
Processing of Capped Intron-Containing Pre-mRNA TAS Reactome
Regulation of Glucokinase by Glucokinase Regulatory Protein TAS Reactome
Regulation of HSF1-mediated heat shock response TAS Reactome
Rev-mediated nuclear export of HIV RNA TAS Reactome
SARS-CoV Infections TAS Reactome
SARS-CoV-2 activates/modulates innate and adaptive immune responses TAS Reactome
SARS-CoV-2 Infection TAS Reactome
SARS-CoV-2-host interactions TAS Reactome
SLC transporter disorders TAS Reactome
snRNP Assembly TAS Reactome
SUMO E3 ligases SUMOylate target proteins TAS Reactome
SUMO E3 ligases SUMOylate target proteins IEA Reactome
SUMOylation TAS Reactome
SUMOylation IEA Reactome
SUMOylation of chromatin organization proteins TAS Reactome
SUMOylation of DNA damage response and repair proteins TAS Reactome
SUMOylation of DNA replication proteins IEA Reactome
SUMOylation of DNA replication proteins TAS Reactome
SUMOylation of RNA binding proteins TAS Reactome
SUMOylation of SUMOylation proteins TAS Reactome
SUMOylation of ubiquitinylation proteins TAS Reactome
Transcriptional regulation by small RNAs TAS Reactome
Transport of Mature mRNA derived from an Intron-Containing Transcript TAS Reactome
Transport of Mature mRNA Derived from an Intronless Transcript TAS Reactome
Transport of Mature mRNAs Derived from Intronless Transcripts TAS Reactome
Transport of Mature Transcript to Cytoplasm TAS Reactome
Transport of Ribonucleoproteins into the Host Nucleus TAS Reactome
Transport of the SLBP Dependant Mature mRNA TAS Reactome
Transport of the SLBP independent Mature mRNA TAS Reactome
tRNA processing TAS Reactome
tRNA processing in the nucleus TAS Reactome
Viral Infection Pathways TAS Reactome
Viral Infection Pathways IEA Reactome
Viral Messenger RNA Synthesis TAS Reactome
Vpr-mediated nuclear import of PICs TAS Reactome





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