Gene description for TNFRSF8
Gene name tumor necrosis factor receptor superfamily, member 8
Gene symbol TNFRSF8
Other names/aliases CD30
D1S166E
Ki-1
Species Homo sapiens
 Database cross references - TNFRSF8
ExoCarta ExoCarta_943
Entrez Gene 943
HGNC 11923
MIM 153243
UniProt P28908  
 TNFRSF8 identified in exosomes derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
B cells 20458337    
 Gene ontology annotations for TNFRSF8
Molecular Function
    transmembrane signaling receptor activity GO:0004888 IEA
Biological Process
    signal transduction GO:0007165 IEA
    negative regulation of cell proliferation GO:0008285 TAS
    cellular response to mechanical stimulus GO:0071260 IEP
    positive regulation of TRAIL biosynthetic process GO:0045556 IDA
    positive regulation of tumor necrosis factor biosynthetic process GO:0042535 IDA
    positive regulation of apoptotic process GO:0043065 IDA
Subcellular Localization
    plasma membrane GO:0005886 IEA
    extracellular exosome GO:0070062 IDA
    cytoplasm GO:0005737 IEA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified TNFRSF8 in exosomes
1
Experiment ID 79
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD81|MHCII
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD81|MHCII
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 81
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD81|MHCII
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
 Protein-protein interactions for TNFRSF8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TNFSF8  
Reconstituted Complex Homo sapiens
2 TDP2 51567
Affinity Capture-Western Homo sapiens
3 TRAF2  
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
4 TRAF1 7185
Invivo Homo sapiens
5 TRIP  
Invitro Homo sapiens
Two-hybrid Homo sapiens
6 TRAF5  
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
7 TRAF3 7187
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which TNFRSF8 is involved
No pathways found





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