Gene description for SLC27A1
Gene name solute carrier family 27 (fatty acid transporter), member 1
Gene symbol SLC27A1
Other names/aliases ACSVL5
FATP
FATP-1
FATP1
Species Homo sapiens
 Database cross references - SLC27A1
ExoCarta ExoCarta_376497
Vesiclepedia VP_376497
Entrez Gene 376497
HGNC 10995
MIM 600691
UniProt Q6PCB7  
 SLC27A1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SLC27A1
Molecular Function
    fatty acid transporter activity GO:0015245 IEA
    long-chain fatty acid-CoA ligase activity GO:0004467 IEA
    nucleotide binding GO:0000166 IEA
    protein homodimerization activity GO:0042803 IEA
    very long-chain fatty acid-CoA ligase activity GO:0031957 IEA
Biological Process
    cellular lipid metabolic process GO:0044255 TAS
    long-chain fatty acid transport GO:0015909 TAS
    phosphatidic acid biosynthetic process GO:0006654 IMP
    phosphatidylethanolamine biosynthetic process GO:0006646 IMP
    adiponectin-activated signaling pathway GO:0033211 IEA
    negative regulation of phospholipid biosynthetic process GO:0071072 IMP
    medium-chain fatty acid transport GO:0001579 IEA
    phosphatidylserine biosynthetic process GO:0006659 IMP
    cardiolipin biosynthetic process GO:0032049 IMP
    positive regulation of protein serine/threonine kinase activity GO:0071902 IEA
    response to cold GO:0009409 IEA
    phosphatidylinositol biosynthetic process GO:0006661 IMP
    long-chain fatty acid metabolic process GO:0001676 IEA
    response to insulin GO:0032868 IEA
    positive regulation of heat generation GO:0031652 IEA
    phosphatidylcholine biosynthetic process GO:0006656 IMP
    transmembrane transport GO:0055085 TAS
    small molecule metabolic process GO:0044281 TAS
    phosphatidylglycerol biosynthetic process GO:0006655 IMP
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    membrane GO:0016020 IDA
    plasma membrane GO:0005886 TAS
    endoplasmic reticulum GO:0005783 IEA
 Experiment description of studies that identified SLC27A1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SLC27A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SLC27A1 is involved
PathwayEvidenceSource
PPARA activates gene expression TAS Reactome
Transport of fatty acids TAS Reactome





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