Gene description for KCNN4
Gene name	potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
Gene symbol	KCNN4
Other names/aliases	IK IK1 IKCA1 KCA4 KCa3.1 SK4 hIKCa1 hKCa4 hSK4
Species	Homo sapiens
Database cross references - KCNN4
ExoCarta	ExoCarta_3783
Vesiclepedia	VP_3783
Entrez Gene	3783
HGNC	6293
MIM	602754
UniProt	O15554
KCNN4 identified in sEVs derived from the following tissue/cell type
Melanoma cells	25950383
Melanoma cells	25950383
Prostate cancer cells	25844599

Gene ontology annotations for KCNN4

Molecular Function     potassium channel activity GO:0005267 TAS     protein binding GO:0005515 IPI     calmodulin binding GO:0005516 IBA     calmodulin binding GO:0005516 IDA     calcium-activated potassium channel activity GO:0015269 IDA     small conductance calcium-activated potassium channel activity GO:0016286 IEA     protein phosphatase binding GO:0019903 IPI     intermediate conductance calcium-activated potassium channel activity GO:0022894 IBA     intermediate conductance calcium-activated potassium channel activity GO:0022894 IDA     protein homodimerization activity GO:0042803 IDA Biological Process     immune system process GO:0002376 IEA     potassium ion transport GO:0006813 TAS     calcium ion transport GO:0006816 IDA     cell volume homeostasis GO:0006884 IEA     defense response GO:0006952 TAS     stabilization of membrane potential GO:0030322 IDA     macropinocytosis GO:0044351 IDA     phospholipid translocation GO:0045332 IEA     saliva secretion GO:0046541 IEA     positive regulation of protein secretion GO:0050714 IEA     positive regulation of T cell receptor signaling pathway GO:0050862 IDA     protein homotetramerization GO:0051289 IDA     establishment of localization in cell GO:0051649 IEA     potassium ion transmembrane transport GO:0071805 IBA     potassium ion transmembrane transport GO:0071805 IDA     positive regulation of potassium ion transmembrane transport GO:1901381 TAS     regulation of calcium ion import across plasma membrane GO:1905664 IDA Subcellular Localization     cytosol GO:0005829 IDA     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 TAS     voltage-gated potassium channel complex GO:0008076 IC     vesicle GO:0031982 IDA     ruffle membrane GO:0032587 IDA     neuron projection GO:0043005 IBA     neuronal cell body GO:0043025 IBA