Gene description for IL23A
Gene name interleukin 23, alpha subunit p19
Gene symbol IL23A
Other names/aliases IL-23
IL-23A
IL23P19
P19
SGRF
Species Homo sapiens
 Database cross references - IL23A
ExoCarta ExoCarta_51561
Vesiclepedia VP_51561
Entrez Gene 51561
HGNC 15488
MIM 605580
UniProt Q9NPF7  
 IL23A identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for IL23A
Molecular Function
    protein binding GO:0005515 IPI
    cytokine activity GO:0005125 IEA
    interleukin-23 receptor binding GO:0045519 IDA
Biological Process
    positive regulation of natural killer cell proliferation GO:0032819 IDA
    positive regulation of defense response to virus by host GO:0002230 ISS
    defense response to virus GO:0051607 IEA
    positive regulation of interleukin-12 production GO:0032735 IDA
    positive regulation of osteoclast differentiation GO:0045672 IDA
    positive regulation of T cell mediated cytotoxicity GO:0001916 ISS
    positive regulation of T-helper 17 cell lineage commitment GO:2000330 ISS
    defense response to Gram-negative bacterium GO:0050829 IDA
    T cell proliferation GO:0042098 IEA
    negative regulation of interleukin-10 production GO:0032693 IMP
    positive regulation of tissue remodeling GO:0034105 IC
    positive regulation of activated T cell proliferation GO:0042104 IDA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA
    positive regulation of interleukin-17 production GO:0032740 IDA
    positive regulation of T-helper 17 type immune response GO:2000318 ISS
    tissue remodeling GO:0048771 IEA
    positive regulation of memory T cell differentiation GO:0043382 ISS
    positive regulation of T cell proliferation GO:0042102 IDA
    positive regulation of tyrosine phosphorylation of Stat4 protein GO:0042520 IDA
    regulation of tyrosine phosphorylation of Stat1 protein GO:0042510 IDA
    positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 IDA
    positive regulation of tumor necrosis factor production GO:0032760 IMP
    positive regulation of neutrophil chemotaxis GO:0090023 IEA
    positive regulation of natural killer cell activation GO:0032816 IC
    inflammatory response GO:0006954 IEA
    positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 IDA
    positive regulation of activation of JAK2 kinase activity GO:0010535 IDA
    positive regulation of NK T cell activation GO:0051135 IDA
    innate immune response GO:0045087 IEA
    positive regulation of NF-kappaB import into nucleus GO:0042346 TAS
    positive regulation of interleukin-10 production GO:0032733 TAS
    positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 IDA
    positive regulation of inflammatory response GO:0050729 IC
    positive regulation of NK T cell proliferation GO:0051142 IDA
    positive regulation of T-helper 1 type immune response GO:0002827 TAS
    positive regulation of interferon-gamma production GO:0032729 TAS
Subcellular Localization
    interleukin-23 complex GO:0070743 IDA
 Experiment description of studies that identified IL23A in exosomes
1
Experiment ID 126
MISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for IL23A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IL23R  
Reconstituted Complex Homo sapiens
2 IL12RB1  
Invivo Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which IL23A is involved
No pathways found





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