Gene description for KCNAB2
Gene name potassium channel, voltage gated subfamily A regulatory beta subunit 2
Gene symbol KCNAB2
Other names/aliases AKR6A5
Species Homo sapiens
 Database cross references - KCNAB2
ExoCarta ExoCarta_8514
Entrez Gene 8514
HGNC 6229
MIM 601142
UniProt Q13303  
 KCNAB2 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for KCNAB2
Molecular Function
    potassium channel regulator activity GO:0015459 IDA
    voltage-gated potassium channel activity GO:0005249 IEA
    aldo-keto reductase (NADP) activity GO:0004033 ISS
Biological Process
    potassium ion transmembrane transport GO:0071805 IEA
    NADPH oxidation GO:0070995 ISS
    oxidation-reduction process GO:0055114 ISS
    hematopoietic progenitor cell differentiation GO:0002244 IEA
    protein heterooligomerization GO:0051291 IEA
    regulation of potassium ion transmembrane transport GO:1901379 IDA
    synaptic transmission GO:0007268 TAS
    regulation of protein localization to cell surface GO:2000008 ISS
Subcellular Localization
    extrinsic component of cytoplasmic side of plasma membrane GO:0031234 ISS
    juxtaparanode region of axon GO:0044224 ISS
    cytosol GO:0005829 ISS
    pinceau fiber GO:1990031 ISS
    membrane GO:0016020 IDA
    voltage-gated potassium channel complex GO:0008076 IDA
    plasma membrane GO:0005886 TAS
    microtubule GO:0005874 ISS
    synapse GO:0045202 IEA
    cell junction GO:0030054 IEA
 Experiment description of studies that identified KCNAB2 in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for KCNAB2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KCNA2  
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
2 KCNA1  
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which KCNAB2 is involved
Voltage gated Potassium channels TAS Reactome

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