Gene description for Rab5b
Gene name RAB5B, member RAS oncogene family
Gene symbol Rab5b
Other names/aliases C030027M18Rik
Species Mus musculus
 Database cross references - Rab5b
ExoCarta ExoCarta_19344
Entrez Gene 19344
UniProt P61021  
 Rab5b identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Rab5b
Molecular Function
    GDP binding GO:0019003 ISO
    GTP-dependent protein binding GO:0030742 ISO
    nucleotide binding GO:0000166 IEA
    protein binding GO:0005515 IPI
    GTPase activity GO:0003924 TAS
    GTP binding GO:0005525 IEA
Biological Process
    plasma membrane to endosome transport GO:0048227 ISO
    metabolic process GO:0008152 ISO
    regulation of endocytosis GO:0030100 IDA
    intracellular protein transport GO:0006886 IBA
    transport GO:0006810 IEA
    antigen processing and presentation GO:0019882 ISO
    protein transport GO:0015031 IEA
    endosome organization GO:0007032 IDA
    Rab protein signal transduction GO:0032482 IBA
    small GTPase mediated signal transduction GO:0007264 IEA
Subcellular Localization
    endocytic vesicle GO:0030139 IDA
    membrane GO:0016020 IEA
    plasma membrane GO:0005886 IBA
    intracellular GO:0005622 ISO
    extracellular exosome GO:0070062 ISO
    endosome GO:0005768 ISO
    early endosome GO:0005769 IBA
 Experiment description of studies that identified Rab5b in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Rab5b
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Rab5b is involved
No pathways found





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