Gene description for QPCTL
Gene name glutaminyl-peptide cyclotransferase-like
Gene symbol QPCTL
Other names/aliases gQC
Species Homo sapiens
 Database cross references - QPCTL
ExoCarta ExoCarta_54814
Vesiclepedia VP_54814
Entrez Gene 54814
HGNC 25952
UniProt Q9NXS2  
 QPCTL identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Mesenchymal stem cells 36408942    
 Gene ontology annotations for QPCTL
Molecular Function
    glutaminyl-peptide cyclotransferase activity GO:0016603 IDA
    zinc ion binding GO:0008270 IDA
Biological Process
    peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase GO:0017186 IDA
Subcellular Localization
    membrane GO:0016020 IDA
    Golgi membrane GO:0000139 IEA
    integral component of membrane GO:0016021 IEA
    Golgi apparatus GO:0005794 IDA
 Experiment description of studies that identified QPCTL in exosomes
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for QPCTL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDKN2C  
Affinity Capture-MS Homo sapiens
2 PAF53  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which QPCTL is involved
No pathways found





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