Gene description for QPCTL
Gene name glutaminyl-peptide cyclotransferase-like
Gene symbol QPCTL
Other names/aliases gQC
Species Homo sapiens
 Database cross references - QPCTL
ExoCarta ExoCarta_54814
Vesiclepedia VP_54814
Entrez Gene 54814
HGNC 25952
UniProt Q9NXS2  
 QPCTL identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Mesenchymal stem cells 36408942    
 Gene ontology annotations for QPCTL
Molecular Function
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IBA
    zinc ion binding GO:0008270 IDA
    glutaminyl-peptide cyclotransferase activity GO:0016603 IBA
    glutaminyl-peptide cyclotransferase activity GO:0016603 IDA
Biological Process
    peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase GO:0017186 IDA
    peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase GO:0017186 IDA
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    Golgi apparatus GO:0005794 IDA
    membrane GO:0016020 HDA
 Experiment description of studies that identified QPCTL in sEVs
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for QPCTL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 ANLN 54443
Affinity Capture-MS Homo sapiens
3 SEC63 11231
Affinity Capture-MS Homo sapiens
4 TMED10 10972
Affinity Capture-MS Homo sapiens
5 UFL1 23376
Affinity Capture-MS Homo sapiens
6 PREX1  
Affinity Capture-MS Homo sapiens
7 FBXL6  
Affinity Capture-MS Homo sapiens
8 KIF14 9928
Affinity Capture-MS Homo sapiens
9 KIF20A 10112
Affinity Capture-MS Homo sapiens
10 RC3H2  
Affinity Capture-MS Homo sapiens
11 CHN2  
Affinity Capture-MS Homo sapiens
12 PEX19 5824
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 OCRL 4952
Affinity Capture-MS Homo sapiens
14 TARDBP 23435
Affinity Capture-MS Homo sapiens
15 CAMK1D 57118
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 YWHAE 7531
Affinity Capture-MS Homo sapiens
17 ARHGEF1 9138
Affinity Capture-MS Homo sapiens
18 TPTE  
Affinity Capture-MS Homo sapiens
19 ARHGEF10L 55160
Affinity Capture-MS Homo sapiens
20 ARHGAP42  
Affinity Capture-MS Homo sapiens
21 CUL3 8452
Affinity Capture-MS Homo sapiens
22 COX15 1355
Affinity Capture-MS Homo sapiens
23 KLHL29  
Affinity Capture-MS Homo sapiens
24 EYA2  
Affinity Capture-MS Homo sapiens
25 FBXO6 26270
Affinity Capture-MS Homo sapiens
26 OTUB1 55611
Affinity Capture-MS Homo sapiens
27 COPE 11316
Affinity Capture-MS Homo sapiens
28 APP 351
Reconstituted Complex Homo sapiens
29 Ect2  
Affinity Capture-MS Mus musculus
30 AURKB 9212
Affinity Capture-MS Homo sapiens
31 ARHGAP26 23092
Affinity Capture-MS Homo sapiens
32 ARHGEF16 27237
Affinity Capture-MS Homo sapiens
33 MYC  
Affinity Capture-MS Homo sapiens
34 FAM13B  
Affinity Capture-MS Homo sapiens
35 KIF23 9493
Affinity Capture-MS Homo sapiens
36 DCAF7 10238
Affinity Capture-MS Homo sapiens
37 CIT 11113
Affinity Capture-MS Homo sapiens
38 NOS2  
Affinity Capture-MS Homo sapiens
39 PRC1 9055
Affinity Capture-MS Homo sapiens
40 AGO3  
Affinity Capture-MS Homo sapiens
41 DDRGK1 65992
Affinity Capture-MS Homo sapiens
42 RNF2  
Affinity Capture-MS Homo sapiens
43 SRF  
Affinity Capture-MS Homo sapiens
44 SPDYE4  
Affinity Capture-MS Homo sapiens
45 FAM20C 56975
Affinity Capture-MS Homo sapiens
46 POLR1E  
Affinity Capture-MS Homo sapiens
47 RC3H1 149041
Affinity Capture-MS Homo sapiens
48 PTCH1  
Affinity Capture-MS Homo sapiens
49 DCP2  
Affinity Capture-MS Homo sapiens
50 C9orf72  
Affinity Capture-MS Homo sapiens
51 CDKN2C  
Affinity Capture-MS Homo sapiens
52 HUWE1 10075
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which QPCTL is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here