Gene description for TMEM126B
Gene name transmembrane protein 126B
Gene symbol TMEM126B
Other names/aliases HT007
Species Homo sapiens
 Database cross references - TMEM126B
ExoCarta ExoCarta_55863
Vesiclepedia VP_55863
Entrez Gene 55863
HGNC 30883
MIM 615533
UniProt Q8IUX1  
 TMEM126B identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for TMEM126B
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    response to food GO:0032094 IEA
    mitochondrial respiratory chain complex I assembly GO:0032981 IBA
    mitochondrial respiratory chain complex I assembly GO:0032981 IMP
    mitochondrial respiratory chain complex I assembly GO:0032981 NAS
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 NAS
    mitochondrial inner membrane GO:0005743 TAS
 Experiment description of studies that identified TMEM126B in exosomes
1
Experiment ID 236
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for TMEM126B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NDUFAF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 MAGEA8  
Affinity Capture-MS Homo sapiens
3 DHX15 1665
Co-fractionation Homo sapiens
4 SPACA1 81833
Affinity Capture-MS Homo sapiens
5 SLC22A6 9356
Affinity Capture-MS Homo sapiens
6 APLNR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 NDUFS5 4725
Affinity Capture-MS Homo sapiens
8 GPR17 2840
Affinity Capture-MS Homo sapiens
9 NDUFS1 4719
Co-fractionation Homo sapiens
10 NDUFA13 51079
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 MFSD4  
Affinity Capture-MS Homo sapiens
12 APOO 79135
Proximity Label-MS Homo sapiens
13 PDCD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 NDUFB5 4711
Affinity Capture-MS Homo sapiens
15 OPRL1 4987
Affinity Capture-MS Homo sapiens
16 APP 351
Reconstituted Complex Homo sapiens
17 SUGP2  
Co-fractionation Homo sapiens
18 SFXN1 94081
Proximity Label-MS Homo sapiens
19 APEX1 328
Affinity Capture-RNA Homo sapiens
20 SLC18A2  
Affinity Capture-MS Homo sapiens
21 MRFAP1L1  
Two-hybrid Homo sapiens
22 FBXW7  
Synthetic Lethality Homo sapiens
23 NDUFS3 4722
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 SLC22A4 6583
Affinity Capture-MS Homo sapiens
25 SLC25A51  
Proximity Label-MS Homo sapiens
26 GPR182  
Affinity Capture-MS Homo sapiens
27 TIMMDC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 ACAD9 28976
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 LDLR 3949
Negative Genetic Homo sapiens
30 NDUFAF4 29078
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 GLMP 112770
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 NDUFB11 54539
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 DHX9 1660
Co-fractionation Homo sapiens
34 AKT1 207
Affinity Capture-Western Homo sapiens
35 DNAJC30  
Proximity Label-MS Homo sapiens
36 NDUFC2 4718
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 NDUFAF3 25915
Affinity Capture-MS Homo sapiens
38 CACNG4  
Affinity Capture-MS Homo sapiens
39 ECSIT 51295
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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