Gene description for TMEM126B
Gene name transmembrane protein 126B
Gene symbol TMEM126B
Other names/aliases HT007
Species Homo sapiens
 Database cross references - TMEM126B
ExoCarta ExoCarta_55863
Entrez Gene 55863
HGNC 30883
MIM 615533
UniProt Q8IUX1  
 TMEM126B identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for TMEM126B
Molecular Function
    molecular_function GO:0003674 ND
    protein binding GO:0005515 IPI
Biological Process
    biological_process GO:0008150 ND
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    mitochondrial membrane GO:0031966 IEA
    cellular_component GO:0005575 ND
 Experiment description of studies that identified TMEM126B in exosomes
1
Experiment ID 236
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for TMEM126B
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TMEM126B is involved
No pathways found





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