Gene description for SLC22A6
Gene name solute carrier family 22 (organic anion transporter), member 6
Gene symbol SLC22A6
Other names/aliases HOAT1
OAT1
PAHT
ROAT1
Species Homo sapiens
 Database cross references - SLC22A6
ExoCarta ExoCarta_9356
Entrez Gene 9356
HGNC 10970
MIM 607582
UniProt Q4U2R8  
 SLC22A6 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for SLC22A6
Molecular Function
    inorganic anion exchanger activity GO:0005452 IDA
    sodium-independent organic anion transmembrane transporter activity GO:0015347 IEA
    protein homodimerization activity GO:0042803 IEA
    organic anion transmembrane transporter activity GO:0008514 IMP
    protein binding GO:0005515 IPI
    chloride ion binding GO:0031404 IEA
Biological Process
    organic anion transport GO:0015711 IMP
    anion transmembrane transport GO:0098656 IEA
    alpha-ketoglutarate transport GO:0015742 IDA
    sodium-independent organic anion transport GO:0043252 IEA
    response to methotrexate GO:0031427 IEA
    transmembrane transport GO:0055085 TAS
    renal tubular secretion GO:0097254 NAS
    protein homooligomerization GO:0051260 IEA
Subcellular Localization
    protein complex GO:0043234 IEA
    extracellular exosome GO:0070062 IDA
    integral component of plasma membrane GO:0005887 IDA
    basolateral plasma membrane GO:0016323 IDA
    caveola GO:0005901 IEA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified SLC22A6 in exosomes
1
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SLC22A6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APPBP2  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which SLC22A6 is involved
PathwayEvidenceSource
Organic anion transport TAS Reactome





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