Gene description for SLC38A7
Gene name solute carrier family 38, member 7
Gene symbol SLC38A7
Other names/aliases SNAT7
Species Homo sapiens
 Database cross references - SLC38A7
ExoCarta ExoCarta_55238
Vesiclepedia VP_55238
Entrez Gene 55238
HGNC 25582
MIM 614236
UniProt Q9NVC3  
 SLC38A7 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for SLC38A7
Molecular Function
    protein binding GO:0005515 IPI
    L-asparagine transmembrane transporter activity GO:0015182 IBA
    L-glutamine transmembrane transporter activity GO:0015186 IBA
    L-asparagine:sodium symporter activity GO:0140901 IDA
    L-glutamine:sodium symporter activity GO:0140902 IDA
    L-glutamine:sodium symporter activity GO:0140902 ISS
Biological Process
    amino acid transmembrane transport GO:0003333 IBA
    sodium ion transport GO:0006814 ISS
    asparagine transport GO:0006867 IDA
    glutamine transport GO:0006868 IDA
    glutamine transport GO:0006868 ISS
Subcellular Localization
    lysosomal membrane GO:0005765 IDA
    membrane GO:0016020 IBA
    axon GO:0030424 ISS
    neuronal cell body GO:0043025 ISS
 Experiment description of studies that identified SLC38A7 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SLC38A7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ERGIC3 51614
Two-hybrid Homo sapiens
2 TMEM52B 120939
Two-hybrid Homo sapiens
3 GJA8  
Two-hybrid Homo sapiens
4 KIR2DL3  
Two-hybrid Homo sapiens
5 CLCN7 1186
Two-hybrid Homo sapiens
6 SLC22A6 9356
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 AQP2 359
Two-hybrid Homo sapiens
8 SLC30A2  
Two-hybrid Homo sapiens
9 CLEC10A  
Two-hybrid Homo sapiens
10 SSMEM1  
Two-hybrid Homo sapiens
11 BTNL9  
Two-hybrid Homo sapiens
12 SLC16A2  
Two-hybrid Homo sapiens
13 YIPF6 286451
Two-hybrid Homo sapiens
14 PANX1 24145
Two-hybrid Homo sapiens
15 TMPRSS11B 132724
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 PDCD1LG2 80380
Two-hybrid Homo sapiens
17 LAMP1 3916
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 PDPN  
Affinity Capture-MS Homo sapiens
19 SPINT1 6692
Two-hybrid Homo sapiens
20 CRELD1 78987
Affinity Capture-MS Homo sapiens
21 MMGT1 93380
Two-hybrid Homo sapiens
22 MUC1 4582
Two-hybrid Homo sapiens
23 ETF1 2107
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 CLDN7 1366
Two-hybrid Homo sapiens
25 SERP2  
Two-hybrid Homo sapiens
26 LYVE1  
Two-hybrid Homo sapiens
27 PDE2A  
Affinity Capture-MS Homo sapiens
28 AMIGO1  
Two-hybrid Homo sapiens
29 TCEA1 6917
Affinity Capture-MS Homo sapiens
30 GPR152  
Two-hybrid Homo sapiens
31 FAM209A 200232
Two-hybrid Homo sapiens
32 CA14 23632
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 VRK1 7443
Affinity Capture-MS Homo sapiens
34 SYPL2  
Two-hybrid Homo sapiens
35 EDA  
Two-hybrid Homo sapiens
36 PLD3 23646
Affinity Capture-MS Homo sapiens
37 GPR42  
Two-hybrid Homo sapiens
38 EVI2B 2124
Two-hybrid Homo sapiens
39 RNF5  
Two-hybrid Homo sapiens
40 ODF4  
Two-hybrid Homo sapiens
41 CPLX4  
Two-hybrid Homo sapiens
42 SLC10A1  
Two-hybrid Homo sapiens
43 IL10RA  
Two-hybrid Homo sapiens
44 OPRM1 4988
Two-hybrid Homo sapiens
45 EEF1A2 1917
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 ACTL6B  
Affinity Capture-MS Homo sapiens
47 TSPAN8 7103
Two-hybrid Homo sapiens
48 KRAS 3845
Negative Genetic Homo sapiens
49 APH1A 51107
Two-hybrid Homo sapiens
50 TMEM237 65062
Two-hybrid Homo sapiens
51 ARL13B 200894
Two-hybrid Homo sapiens
52 LY6G6C  
Two-hybrid Homo sapiens
53 SCN3B  
Two-hybrid Homo sapiens
54 GGA1 26088
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 FCER1G 2207
Two-hybrid Homo sapiens
56 KIAA1644  
Two-hybrid Homo sapiens
57 ACBD5 91452
Two-hybrid Homo sapiens
58 AQP9  
Two-hybrid Homo sapiens
59 GJB5  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which SLC38A7 is involved
No pathways found





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