Gene description for PDCD1LG2
Gene name programmed cell death 1 ligand 2
Gene symbol PDCD1LG2
Other names/aliases B7DC
Btdc
CD273
PD-L2
PDCD1L2
PDL2
bA574F11.2
Species Homo sapiens
 Database cross references - PDCD1LG2
ExoCarta ExoCarta_80380
Vesiclepedia VP_80380
Entrez Gene 80380
HGNC 18731
MIM 605723
UniProt Q9BQ51  
 PDCD1LG2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for PDCD1LG2
Molecular Function
    molecular_function GO:0003674 ND
Biological Process
    negative regulation of activated T cell proliferation GO:0046007 IMP
    positive regulation of T cell proliferation GO:0042102 IEA
    immune response GO:0006955 NAS
    negative regulation of interferon-gamma production GO:0032689 IMP
    T cell costimulation GO:0031295 TAS
    negative regulation of interleukin-10 production GO:0032693 IMP
Subcellular Localization
    plasma membrane GO:0005886 TAS
    extracellular exosome GO:0070062 IDA
    endomembrane system GO:0012505 IEA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified PDCD1LG2 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PDCD1LG2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PDCD1  
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which PDCD1LG2 is involved
PathwayEvidenceSource
PD-1 signaling TAS Reactome





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