Gene description for PDCD1LG2
Gene name programmed cell death 1 ligand 2
Gene symbol PDCD1LG2
Other names/aliases B7DC
Btdc
CD273
PD-L2
PDCD1L2
PDL2
bA574F11.2
Species Homo sapiens
 Database cross references - PDCD1LG2
ExoCarta ExoCarta_80380
Vesiclepedia VP_80380
Entrez Gene 80380
HGNC 18731
MIM 605723
UniProt Q9BQ51  
 PDCD1LG2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for PDCD1LG2
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    adaptive immune response GO:0002250 IEA
    immune response GO:0006955 IBA
    immune response GO:0006955 NAS
    cell surface receptor signaling pathway GO:0007166 IBA
    T cell costimulation GO:0031295 IBA
    negative regulation of type II interferon production GO:0032689 IMP
    negative regulation of interleukin-10 production GO:0032693 IMP
    positive regulation of T cell proliferation GO:0042102 IBA
    negative regulation of T cell proliferation GO:0042130 IBA
    negative regulation of activated T cell proliferation GO:0046007 IMP
    cellular response to lipopolysaccharide GO:0071222 IBA
Subcellular Localization
    extracellular region GO:0005576 IEA
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IBA
    endomembrane system GO:0012505 IEA
 Experiment description of studies that identified PDCD1LG2 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PDCD1LG2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ALCAM 214
Affinity Capture-MS Homo sapiens
2 TMEM239  
Two-hybrid Homo sapiens
3 LRP10 26020
Two-hybrid Homo sapiens
4 SMIM3  
Two-hybrid Homo sapiens
5 TMEM218  
Two-hybrid Homo sapiens
6 MTERF3  
Affinity Capture-MS Homo sapiens
7 SLC38A1 81539
Two-hybrid Homo sapiens
8 PCDH1 5097
Affinity Capture-MS Homo sapiens
9 PDCD1  
Reconstituted Complex Homo sapiens
10 TMEM147 10430
Two-hybrid Homo sapiens
11 SBDSP1  
Affinity Capture-MS Homo sapiens
12 PODXL2 50512
Affinity Capture-MS Homo sapiens
13 FUT8 2530
Affinity Capture-MS Homo sapiens
14 TAS2R10  
Two-hybrid Homo sapiens
15 RAB35 11021
Affinity Capture-MS Homo sapiens
16 SLC38A7 55238
Two-hybrid Homo sapiens
17 MFSD6 54842
Two-hybrid Homo sapiens
18 RAB4A 5867
Affinity Capture-MS Homo sapiens
19 ATP6V0C 527
Two-hybrid Homo sapiens
20 C16orf58 64755
Two-hybrid Homo sapiens
21 SLC41A2 84102
Two-hybrid Homo sapiens
22 GPR37L1  
Two-hybrid Homo sapiens
23 NCR3LG1 374383
Affinity Capture-MS Homo sapiens
24 SLC39A11  
Affinity Capture-MS Homo sapiens
25 AUNIP  
Affinity Capture-MS Homo sapiens
26 GALNT15  
Two-hybrid Homo sapiens
27 KTN1 3895
Two-hybrid Homo sapiens
28 LGALS3 3958
Affinity Capture-MS Homo sapiens
29 TMEM97 27346
Two-hybrid Homo sapiens
30 SLC7A1 6541
Two-hybrid Homo sapiens
31 TNFSF9  
Affinity Capture-MS Homo sapiens
32 ITM2B 9445
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PDCD1LG2 is involved
PathwayEvidenceSource
Adaptive Immune System TAS Reactome
Costimulation by the CD28 family TAS Reactome
Immune System TAS Reactome
PD-1 signaling TAS Reactome





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