Gene description for PCDH1
Gene name protocadherin 1
Gene symbol PCDH1
Other names/aliases PC42
PCDH42
Species Homo sapiens
 Database cross references - PCDH1
ExoCarta ExoCarta_5097
Entrez Gene 5097
HGNC 8655
MIM 603626
UniProt Q08174  
 PCDH1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for PCDH1
Molecular Function
    calcium ion binding GO:0005509 IEA
Biological Process
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
    nervous system development GO:0007399 TAS
    cell-cell signaling GO:0007267 TAS
Subcellular Localization
    cell-cell junction GO:0005911 TAS
    integral component of plasma membrane GO:0005887 TAS
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified PCDH1 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for PCDH1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SMAD3  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PCDH1 is involved
No pathways found





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