Gene description for NDUFB1
Gene name NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
Gene symbol NDUFB1
Other names/aliases CI-MNLL
CI-SGDH
MNLL
Species Homo sapiens
 Database cross references - NDUFB1
ExoCarta ExoCarta_4707
Entrez Gene 4707
HGNC 7695
MIM 603837
UniProt O75438  
 NDUFB1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for NDUFB1
Molecular Function
    NADH dehydrogenase (ubiquinone) activity GO:0008137 NAS
Biological Process
    cellular metabolic process GO:0044237 TAS
    small molecule metabolic process GO:0044281 TAS
    mitochondrial electron transport, NADH to ubiquinone GO:0006120 NAS
    respiratory electron transport chain GO:0022904 TAS
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    extracellular exosome GO:0070062 IDA
    mitochondrial respiratory chain complex I GO:0005747 NAS
    mitochondrial inner membrane GO:0005743 TAS
 Experiment description of studies that identified NDUFB1 in exosomes
1
Experiment ID 235
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for NDUFB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NDUFA5  
Two-hybrid Homo sapiens
2 EWSR1 2130
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which NDUFB1 is involved
PathwayEvidenceSource
Respiratory electron transport TAS Reactome





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