Gene description for FNDC1
Gene name fibronectin type III domain containing 1
Gene symbol FNDC1
Other names/aliases AGS8
FNDC2
MEL4B3
bA243O10.1
dJ322A24.1
Species Homo sapiens
 Database cross references - FNDC1
ExoCarta ExoCarta_84624
Entrez Gene 84624
HGNC 21184
MIM 609991
UniProt Q4ZHG4  
 FNDC1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for FNDC1
Biological Process
    regulation of protein transport GO:0051223 IEA
    positive regulation of cardiac muscle cell apoptotic process GO:0010666 IEA
    positive regulation of protein phosphorylation GO:0001934 IEA
    cellular response to hypoxia GO:0071456 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    plasma membrane GO:0005886 IEA
    mitochondrial membrane GO:0031966 IEA
    cell-cell junction GO:0005911 IEA
    extracellular region GO:0005576 IEA
 Experiment description of studies that identified FNDC1 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for FNDC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which FNDC1 is involved
No pathways found





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