Gene description for FGA
Gene name fibrinogen alpha chain
Gene symbol FGA
Other names/aliases Fib2
Species Homo sapiens
 Database cross references - FGA
ExoCarta ExoCarta_2243
Vesiclepedia VP_2243
Entrez Gene 2243
HGNC 3661
MIM 134820
UniProt P02671  
 FGA identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
Hepatocytes 26054723    
Mesenchymal stem cells Unpublished / Not applicable
Mesenchymal stem cells 36408942    
Plasma 19028452    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Thymus 23844026    
Urine 15326289    
Urine 19056867    
 Gene ontology annotations for FGA
Molecular Function
    signaling receptor binding GO:0005102 IDA
    structural molecule activity GO:0005198 IDA
    structural molecule activity GO:0005198 IMP
    extracellular matrix structural constituent GO:0005201 HDA
    extracellular matrix structural constituent GO:0005201 RCA
    protein binding GO:0005515 IPI
    protein-macromolecule adaptor activity GO:0030674 IBA
    metal ion binding GO:0046872 IEA
    cell adhesion molecule binding GO:0050839 IDA
Biological Process
    adaptive immune response GO:0002250 IEA
    cell-matrix adhesion GO:0007160 IDA
    plasminogen activation GO:0031639 IDA
    positive regulation of heterotypic cell-cell adhesion GO:0034116 IBA
    positive regulation of heterotypic cell-cell adhesion GO:0034116 IDA
    fibrinolysis GO:0042730 IBA
    fibrinolysis GO:0042730 IDA
    induction of bacterial agglutination GO:0043152 IDA
    innate immune response GO:0045087 IEA
    positive regulation of vasoconstriction GO:0045907 IDA
    positive regulation of exocytosis GO:0045921 IDA
    positive regulation of protein secretion GO:0050714 IDA
    protein polymerization GO:0051258 IDA
    response to calcium ion GO:0051592 IDA
    protein-containing complex assembly GO:0065003 IDA
    protein-containing complex assembly GO:0065003 IMP
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA
    platelet aggregation GO:0070527 HMP
    platelet aggregation GO:0070527 IBA
    platelet aggregation GO:0070527 IDA
    blood coagulation, common pathway GO:0072377 IBA
    blood coagulation, common pathway GO:0072377 IMP
    blood coagulation, fibrin clot formation GO:0072378 IDA
    positive regulation of peptide hormone secretion GO:0090277 IDA
    positive regulation of substrate adhesion-dependent cell spreading GO:1900026 NAS
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 IDA
    negative regulation of blood coagulation, common pathway GO:2000261 TAS
    negative regulation of endothelial cell apoptotic process GO:2000352 IDA
Subcellular Localization
    extracellular region GO:0005576 NAS
    extracellular region GO:0005576 TAS
    fibrinogen complex GO:0005577 IBA
    fibrinogen complex GO:0005577 IDA
    extracellular space GO:0005615 IDA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum lumen GO:0005788 TAS
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IDA
    cell surface GO:0009986 IDA
    platelet alpha granule GO:0031091 IDA
    platelet alpha granule lumen GO:0031093 TAS
    collagen-containing extracellular matrix GO:0062023 HDA
    extracellular exosome GO:0070062 HDA
    blood microparticle GO:0072562 HDA
    extracellular vesicle GO:1903561 HDA
 Experiment description of studies that identified FGA in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 494
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 496
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
8
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
9
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
10
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
11
Experiment ID 44
MISEV standards
✔
IEM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19028452    
Organism Homo sapiens
Experiment description Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein.
Authors "Looze C, Yui D, Leung L, Ingham M, Kaler M, Yao X, Wu WW, Shen RF, Daniels MP, Levine SJ"
Journal name BBRC
Publication year 2009
Sample Plasma
Sample name Plasma
Isolation/purification methods Filtration
Size exclusion
Sucrose density gradient
Flotation density 1.15-1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
12
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
14
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
15
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
16
Experiment ID 13
MISEV standards
✔
IEM
Biophysical techniques
✔
Alix|RAB4|RAB5B|RAB11|TSG101|CD9|AQP2|AQP1
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15326289    
Organism Homo sapiens
Experiment description Identification and proteomic profiling of exosomes in human urine.
Authors "Pisitkun T, Shen RF, Knepper MA"
Journal name PNAS
Publication year 2004
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
17
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for FGA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CERS3  
Affinity Capture-MS Homo sapiens
2 FNDC1 84624
Affinity Capture-MS Homo sapiens
3 MIS12  
Affinity Capture-MS Homo sapiens
4 TRIM21 6737
Affinity Capture-MS Homo sapiens
5 RING1 6015
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 CIR1  
Affinity Capture-MS Homo sapiens
7 SNX27 81609
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 RHBDD1 84236
Affinity Capture-MS Homo sapiens
9 PLAT 5327
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
10 PRRC2A 7916
Two-hybrid Homo sapiens
11 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
12 AGPAT1 10554
Affinity Capture-MS Homo sapiens
13 C18orf21  
Affinity Capture-MS Homo sapiens
14 FANCD2  
Affinity Capture-MS Homo sapiens
15 WIPF2 147179
Affinity Capture-MS Homo sapiens
16 MTIF2 4528
Proximity Label-MS Homo sapiens
17 SCGB1D1  
Affinity Capture-MS Homo sapiens
18 PRNP 5621
Affinity Capture-MS Homo sapiens
19 GJA1 2697
Affinity Capture-MS Homo sapiens
20 DDX19B 11269
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 CDH5  
Reconstituted Complex Homo sapiens
22 ALB 213
Affinity Capture-MS Homo sapiens
23 ALDH2 217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 HIST1H2BJ 8970
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 ASB6 140459
Affinity Capture-MS Homo sapiens
26 HRG 3273
Reconstituted Complex Homo sapiens
27 FGB 2244
Cross-Linking-MS (XL-MS) Homo sapiens
Co-crystal Structure Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
28 TRIM33 51592
Affinity Capture-MS Homo sapiens
29 UBC 7316
Reconstituted Complex Homo sapiens
30 SRP14 6727
Affinity Capture-MS Homo sapiens
31 ST6GALNAC6 30815
Affinity Capture-MS Homo sapiens
32 FGA 2243
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
33 SLC9A5  
Affinity Capture-MS Homo sapiens
34 MBNL1 4154
Affinity Capture-MS Homo sapiens
35 SOX2  
Affinity Capture-MS Homo sapiens
36 APP 351
Reconstituted Complex Homo sapiens
37 SLC6A1  
Affinity Capture-MS Homo sapiens
38 CHRDL2 25884
Affinity Capture-MS Homo sapiens
39 SYCE1L  
Two-hybrid Homo sapiens
40 P2RX6  
Affinity Capture-MS Homo sapiens
41 KHDRBS2  
Affinity Capture-MS Homo sapiens
42 TMEM43 79188
Two-hybrid Homo sapiens
43 MAPK6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 TPM1 7168
Two-hybrid Homo sapiens
45 SSUH2  
Affinity Capture-MS Homo sapiens
46 WHSC1 7468
Affinity Capture-MS Homo sapiens
47 FGG 2266
Co-crystal Structure Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
48 F2 2147
Co-crystal Structure Homo sapiens
Co-localization Homo sapiens
49 SARAF  
Affinity Capture-MS Homo sapiens
50 ADAM21  
Affinity Capture-MS Homo sapiens
51 YWHAQ 10971
Affinity Capture-MS Homo sapiens
52 GOT1 2805
Affinity Capture-MS Homo sapiens
53 THBS1 7057
Reconstituted Complex Homo sapiens
54 FBXW7  
Synthetic Lethality Homo sapiens
55 NID1 4811
Reconstituted Complex Homo sapiens
56 DDX1 1653
Affinity Capture-MS Homo sapiens
57 OR2A4 79541
Affinity Capture-MS Homo sapiens
58 LGALS3 3958
Affinity Capture-MS Homo sapiens
59 HCN1  
Affinity Capture-MS Homo sapiens
60 TPM3 7170
Two-hybrid Homo sapiens
61 F13A1 2162
Co-crystal Structure Homo sapiens
62 CCR1  
Affinity Capture-MS Homo sapiens
63 KLK10 5655
Affinity Capture-MS Homo sapiens
64 STX17 55014
Affinity Capture-MS Homo sapiens
65 GNG8  
Affinity Capture-MS Homo sapiens
66 ASB7  
Affinity Capture-MS Homo sapiens
67 UBE2U  
Affinity Capture-MS Homo sapiens
68 PHF11 51131
Affinity Capture-MS Homo sapiens
69 APOA1 335
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
70 STX2 2054
Two-hybrid Homo sapiens
71 TCEB3B  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FGA is involved
PathwayEvidenceSource
Adaptive Immune System TAS Reactome
Amyloid fiber formation TAS Reactome
Antigen processing-Cross presentation TAS Reactome
Class I MHC mediated antigen processing & presentation TAS Reactome
Common Pathway of Fibrin Clot Formation TAS Reactome
Disease TAS Reactome
Diseases associated with the TLR signaling cascade TAS Reactome
Diseases of Immune System TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
ER-Phagosome pathway TAS Reactome
Extracellular matrix organization TAS Reactome
Formation of Fibrin Clot (Clotting Cascade) TAS Reactome
GRB2:SOS provides linkage to MAPK signaling for Integrins TAS Reactome
Hemostasis TAS Reactome
Immune System TAS Reactome
Innate Immune System TAS Reactome
Integrin cell surface interactions TAS Reactome
Integrin signaling TAS Reactome
IRAK4 deficiency (TLR2/4) TAS Reactome
MAP2K and MAPK activation TAS Reactome
MAPK family signaling cascades TAS Reactome
MAPK1/MAPK3 signaling TAS Reactome
Metabolism of proteins TAS Reactome
MyD88 deficiency (TLR2/4) TAS Reactome
MyD88:MAL(TIRAP) cascade initiated on plasma membrane TAS Reactome
Oncogenic MAPK signaling TAS Reactome
p130Cas linkage to MAPK signaling for integrins TAS Reactome
Paradoxical activation of RAF signaling by kinase inactive BRAF TAS Reactome
Platelet activation, signaling and aggregation TAS Reactome
Platelet Aggregation (Plug Formation) TAS Reactome
Platelet degranulation TAS Reactome
Post-translational protein modification TAS Reactome
Post-translational protein phosphorylation TAS Reactome
RAF/MAP kinase cascade TAS Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) TAS Reactome
Regulation of TLR by endogenous ligand TAS Reactome
Response to elevated platelet cytosolic Ca2+ TAS Reactome
Signal Transduction TAS Reactome
Signaling by BRAF and RAF1 fusions TAS Reactome
Signaling by high-kinase activity BRAF mutants TAS Reactome
Signaling by moderate kinase activity BRAF mutants TAS Reactome
Signaling by RAF1 mutants TAS Reactome
Signaling by RAS mutants TAS Reactome
Signaling downstream of RAS mutants TAS Reactome
Toll Like Receptor 2 (TLR2) Cascade TAS Reactome
Toll Like Receptor 4 (TLR4) Cascade TAS Reactome
Toll Like Receptor TLR1:TLR2 Cascade TAS Reactome
Toll Like Receptor TLR6:TLR2 Cascade TAS Reactome
Toll-like Receptor Cascades TAS Reactome





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