Gene description for RREB1
Gene name ras responsive element binding protein 1
Gene symbol RREB1
Other names/aliases FINB
HNT
LZ321
RREB-1
Zep-1
Species Homo sapiens
 Database cross references - RREB1
ExoCarta ExoCarta_6239
Entrez Gene 6239
HGNC 10449
MIM 602209
UniProt Q92766  
 RREB1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Urine 19056867    
 Gene ontology annotations for RREB1
Molecular Function
    metal ion binding GO:0046872 IEA
    RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 IMP
    sequence-specific DNA binding transcription factor activity GO:0003700 IEA
Biological Process
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP
    positive regulation of epithelial cell migration GO:0010634 IMP
    positive regulation of mammary gland epithelial cell proliferation GO:0033601 IMP
    multicellular organismal development GO:0007275 TAS
    Ras protein signal transduction GO:0007265 TAS
    transcription from RNA polymerase II promoter GO:0006366 TAS
    regulation of transcription, DNA-templated GO:0006355 TAS
    positive regulation of lamellipodium morphogenesis GO:2000394 IMP
    positive regulation of wound healing, spreading of epidermal cells GO:1903691 IMP
    positive regulation of transcription, DNA-templated GO:0045893 TAS
    positive regulation of substrate adhesion-dependent cell spreading GO:1900026 IMP
Subcellular Localization
    cytoplasm GO:0005737 TAS
    nuclear speck GO:0016607 IEA
    extracellular exosome GO:0070062 IDA
    nuclear body GO:0016604 TAS
    nucleolus GO:0005730 IDA
    nucleus GO:0005634 TAS
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified RREB1 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for RREB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which RREB1 is involved
No pathways found





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