Gene description for NUBP1
Gene name nucleotide binding protein 1
Gene symbol NUBP1
Other names/aliases NBP
NBP1
NBP35
Species Homo sapiens
 Database cross references - NUBP1
ExoCarta ExoCarta_4682
Entrez Gene 4682
HGNC 8041
MIM 600280
UniProt P53384  
 NUBP1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for NUBP1
Molecular Function
    nucleotide binding GO:0000166 TAS
    4 iron, 4 sulfur cluster binding GO:0051539 IEA
    iron-sulfur cluster binding GO:0051536 IDA
    metal ion binding GO:0046872 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
Biological Process
    negative regulation of centrosome duplication GO:0010826 IEA
    iron-sulfur cluster assembly GO:0016226 IMP
    cellular iron ion homeostasis GO:0006879 IMP
    cell growth GO:0016049 IMP
    centrosome localization GO:0051642 IEA
    small molecule metabolic process GO:0044281 TAS
    protein localization to cell cortex GO:0072697 IEA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 IDA
    extracellular exosome GO:0070062 IDA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified NUBP1 in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for NUBP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NDN  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which NUBP1 is involved
PathwayEvidenceSource
Cytosolic iron-sulfur cluster assembly IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here