Gene description for ZBTB10
Gene name zinc finger and BTB domain containing 10
Gene symbol ZBTB10
Other names/aliases RINZF
Species Homo sapiens
 Database cross references - ZBTB10
ExoCarta ExoCarta_65986
Vesiclepedia VP_65986
Entrez Gene 65986
HGNC 30953
UniProt Q96DT7  
 ZBTB10 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ZBTB10
Molecular Function
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IBA
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 ISS
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 ISS
    protein binding GO:0005515 IPI
    telomeric DNA binding GO:0042162 IDA
    metal ion binding GO:0046872 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 ISS
    regulation of transcription by RNA polymerase II GO:0006357 IBA
Subcellular Localization
    chromosome, telomeric region GO:0000781 IDA
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified ZBTB10 in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for ZBTB10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD3EAP  
Proximity Label-MS Homo sapiens
2 RPL11 6135
Affinity Capture-MS Homo sapiens
3 DDX6 1656
Two-hybrid Homo sapiens
4 PRICKLE3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 ZNF576  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 MIF 4282
Affinity Capture-MS Homo sapiens
7 PDLIM7 9260
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
9 ZBTB2 57621
Affinity Capture-MS Homo sapiens
10 SIRT6  
Affinity Capture-MS Homo sapiens
11 PARP1 142
Proximity Label-MS Homo sapiens
12 GOLGA8G  
Affinity Capture-MS Homo sapiens
13 COIL  
Proximity Label-MS Homo sapiens
14 HRAS 3265
Reconstituted Complex Homo sapiens
15 RBPJ 3516
Affinity Capture-MS Homo sapiens
16 TP53BP1 7158
Affinity Capture-MS Homo sapiens
17 FOXP1 27086
Affinity Capture-MS Homo sapiens
18 PIP 5304
Affinity Capture-MS Homo sapiens
19 MOB3C  
Two-hybrid Homo sapiens
20 ZNF232  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 KLHL29  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 RAMP1  
Affinity Capture-MS Homo sapiens
23 RPL35A 6165
Affinity Capture-MS Homo sapiens
24 NF2 4771
Affinity Capture-MS Homo sapiens
25 KLF5  
Proximity Label-MS Homo sapiens
26 EHHADH 1962
Two-hybrid Homo sapiens
27 ZNF169 169841
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 C19orf66  
Affinity Capture-MS Homo sapiens
29 MIB1 57534
Affinity Capture-MS Homo sapiens
30 FBXO38 81545
Proximity Label-MS Homo sapiens
31 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 RNF8  
Two-hybrid Homo sapiens
33 LSM4 25804
Two-hybrid Homo sapiens
34 PHF1  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
35 MORF4L2  
Two-hybrid Homo sapiens
36 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
37 NFIX 4784
Proximity Label-MS Homo sapiens
38 CHCHD4  
Affinity Capture-MS Homo sapiens
39 LACC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 DIEXF  
Two-hybrid Homo sapiens
41 CEP192 55125
Affinity Capture-MS Homo sapiens
42 MORF4L1  
Two-hybrid Homo sapiens
43 SPATA20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 BATF3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 ELK3  
Proximity Label-MS Homo sapiens
46 CSNK2B 1460
Affinity Capture-MS Homo sapiens
47 CENPA  
Proximity Label-MS Homo sapiens
48 ATXN7L1 222255
Affinity Capture-MS Homo sapiens
49 DHX40  
Proximity Label-MS Homo sapiens
50 BRD1 23774
Affinity Capture-MS Homo sapiens
51 CEP19  
Two-hybrid Homo sapiens
52 SNRNP200 23020
Co-fractionation Homo sapiens
53 RFPL4B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 SRP9 6726
Affinity Capture-MS Homo sapiens
55 LHX1  
Proximity Label-MS Homo sapiens
56 RARRES1 5918
Affinity Capture-MS Homo sapiens
57 IRF8  
Proximity Label-MS Homo sapiens
58 FOXK2  
Affinity Capture-MS Homo sapiens
59 MYO15B 80022
Two-hybrid Homo sapiens
60 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
61 ZBTB46  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 XAGE1B  
Affinity Capture-MS Homo sapiens
63 HIRA  
Affinity Capture-MS Homo sapiens
64 RHPN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 ZNF691  
Affinity Capture-MS Homo sapiens
66 NUBP1 4682
Affinity Capture-MS Homo sapiens
67 S100B 6285
Affinity Capture-MS Homo sapiens
68 MAGOHB 55110
Two-hybrid Homo sapiens
69 PACRGL  
Two-hybrid Homo sapiens
70 KLF16  
Proximity Label-MS Homo sapiens
71 FOXQ1  
Affinity Capture-MS Homo sapiens
72 ZNF460  
Affinity Capture-MS Homo sapiens
73 POLR1E  
Proximity Label-MS Homo sapiens
74 HPS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 MBD3L2  
Affinity Capture-MS Homo sapiens
76 FOXJ3  
Affinity Capture-MS Homo sapiens
77 FBXL17  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
78 ZNF417  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
79 IPO8 10526
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 ARHGAP18 93663
Affinity Capture-MS Homo sapiens
81 USP20  
Two-hybrid Homo sapiens
82 PAX6  
Proximity Label-MS Homo sapiens
83 TEX19  
Affinity Capture-MS Homo sapiens
84 MYB  
Proximity Label-MS Homo sapiens
85 FEV  
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ZBTB10 is involved
No pathways found





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