Gene description for ELK4
Gene name ELK4, ETS-domain protein (SRF accessory protein 1)
Gene symbol ELK4
Other names/aliases SAP1
Species Homo sapiens
 Database cross references - ELK4
ExoCarta ExoCarta_2005
Entrez Gene 2005
HGNC 3326
MIM 600246
UniProt P28324  
 ELK4 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for ELK4
Molecular Function
    sequence-specific DNA binding GO:0043565 IEA
    sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0000981 IBA
    chromatin binding GO:0003682 IDA
    protein binding GO:0005515 IPI
    DNA binding GO:0003677 TAS
    core promoter binding GO:0001047 TAS
    sequence-specific DNA binding transcription factor activity GO:0003700 NAS
    transcription cofactor activity GO:0003712 TAS
Biological Process
    histone H3 deacetylation GO:0070932 IDA
    transcription from RNA polymerase II promoter GO:0006366 IBA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP
    cell differentiation GO:0030154 IBA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified ELK4 in exosomes
Experiment ID 226
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for ELK4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FOS 2353
Invivo Homo sapiens
2 BRCA1 672
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
3 SRF  
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which ELK4 is involved
No pathways found

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