Gene description for DOK4
Gene name docking protein 4
Gene symbol DOK4
Other names/aliases IRS-5
IRS5
Species Homo sapiens
 Database cross references - DOK4
ExoCarta ExoCarta_55715
Entrez Gene 55715
HGNC 19868
MIM 608333
UniProt Q8TEW6  
 DOK4 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for DOK4
Molecular Function
    protein binding GO:0005515 IPI
    receptor signaling protein activity GO:0005057 IEA
    insulin receptor binding GO:0005158 IEA
Biological Process
    nervous system development GO:0007399 IEA
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IEA
    MAPK cascade GO:0000165 IEA
Subcellular Localization
    intracellular GO:0005622 IEA
 Experiment description of studies that identified DOK4 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for DOK4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RET 5979
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which DOK4 is involved
No pathways found





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