Gene description for BCL11A
Gene name B-cell CLL/lymphoma 11A (zinc finger protein)
Gene symbol BCL11A
Other names/aliases BCL11A-L
BCL11A-S
BCL11A-XL
BCL11a-M
CTIP1
EVI9
HBFQTL5
ZNF856
Species Homo sapiens
 Database cross references - BCL11A
ExoCarta ExoCarta_53335
Vesiclepedia VP_53335
Entrez Gene 53335
HGNC 13221
MIM 606557
UniProt Q9H165  
 BCL11A identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for BCL11A
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    transcription regulatory region nucleic acid binding GO:0001067 IDA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IDA
    DNA-binding transcription factor activity GO:0003700 IBA
    transcription coregulator activity GO:0003712 IDA
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 IEA
    protein homodimerization activity GO:0042803 IPI
    metal ion binding GO:0046872 IEA
    protein heterodimerization activity GO:0046982 IPI
    DNA-binding transcription factor binding GO:0140297 IPI
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    positive regulation of gene expression GO:0010628 IEA
    positive regulation of neuron projection development GO:0010976 IDA
    negative regulation of neuron projection development GO:0010977 IDA
    protein sumoylation GO:0016925 ISS
    negative regulation of axon extension GO:0030517 ISS
    negative regulation of protein homooligomerization GO:0032463 IC
    positive regulation of transcription by RNA polymerase II GO:0045944 ISS
    negative regulation of collateral sprouting GO:0048671 IMP
    positive regulation of collateral sprouting GO:0048672 IMP
    regulation of dendrite development GO:0050773 IMP
    negative regulation of dendrite extension GO:1903860 IEA
    negative regulation of neuron remodeling GO:1904800 IEA
    cellular response to L-glutamate GO:1905232 IEA
    negative regulation of dendrite development GO:2000171 IBA
    negative regulation of dendrite development GO:2000171 IMP
    negative regulation of branching morphogenesis of a nerve GO:2000173 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 TAS
    nuclear matrix GO:0016363 IEA
    SWI/SNF complex GO:0016514 IDA
    paraspeckles GO:0042382 IDA
    postsynapse GO:0098794 IEA
 Experiment description of studies that identified BCL11A in sEVs
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for BCL11A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NFAM1  
Two-hybrid Homo sapiens
2 GATAD2B 57459
Affinity Capture-MS Homo sapiens
3 NR2F6  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
4 HDAC2 3066
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 COIL  
Proximity Label-MS Homo sapiens
6 FEV  
Proximity Label-MS Homo sapiens
7 ZNF296  
Affinity Capture-MS Homo sapiens
8 ACTC1 70
Two-hybrid Homo sapiens
9 GMCL1P1  
Two-hybrid Homo sapiens
10 SAP30 8819
Affinity Capture-MS Homo sapiens
11 APP 351
Reconstituted Complex Homo sapiens
12 LMO1  
Two-hybrid Homo sapiens
13 MTF2  
Affinity Capture-MS Homo sapiens
14 CHAF1A  
Affinity Capture-MS Homo sapiens
15 SMARCA1 6594
Affinity Capture-MS Homo sapiens
16 CDK2AP1  
Affinity Capture-MS Homo sapiens
17 NR2F2  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
18 ARID4B  
Affinity Capture-MS Homo sapiens
19 ZNF512B  
Affinity Capture-MS Homo sapiens
20 POLR1E  
Proximity Label-MS Homo sapiens
21 MBD3L2  
Affinity Capture-MS Homo sapiens
22 EED  
Affinity Capture-MS Homo sapiens
23 ZNF219  
Affinity Capture-MS Homo sapiens
24 PHF1  
Affinity Capture-MS Homo sapiens
25 NR2E3  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
26 CHD3 1107
Affinity Capture-MS Homo sapiens
27 MTA2 9219
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
28 BCL11B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 PHF20L1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 RBBP7 5931
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 SHPRH  
Affinity Capture-MS Homo sapiens
32 C17orf49 124944
Affinity Capture-MS Homo sapiens
33 LIN52  
Affinity Capture-MS Homo sapiens
34 GOLGA2 2801
Proximity Label-MS Homo sapiens
35 UBE2I 7329
Biochemical Activity Homo sapiens
36 AIM2  
Affinity Capture-MS Homo sapiens
37 BPTF 2186
Affinity Capture-MS Homo sapiens
38 NR2E1  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
39 SUZ12  
Affinity Capture-MS Homo sapiens
40 MYBL2 4605
Affinity Capture-MS Homo sapiens
41 MBD2 8932
Affinity Capture-MS Homo sapiens
42 BCL6  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
43 CHD5 26038
Affinity Capture-MS Homo sapiens
44 SUDS3  
Affinity Capture-MS Homo sapiens
45 MRPL22  
Affinity Capture-MS Homo sapiens
46 MBD3 53615
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
47 CEBPA  
Proximity Label-MS Homo sapiens
48 SP100 6672
Affinity Capture-MS Homo sapiens
49 BCL11A 53335
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
50 ZBTB2 57621
Affinity Capture-MS Homo sapiens
51 ZAK 51776
Affinity Capture-MS Homo sapiens
52 CDCA3 83461
Two-hybrid Homo sapiens
53 SMARCA5 8467
Affinity Capture-MS Homo sapiens
54 ZBTB24  
Two-hybrid Homo sapiens
55 CUL3 8452
Affinity Capture-MS Homo sapiens
56 PIAS3  
Affinity Capture-Western Homo sapiens
57 BRMS1L  
Affinity Capture-MS Homo sapiens
58 FGFR2 2263
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 LIN9  
Affinity Capture-MS Homo sapiens
60 YME1L1 10730
Two-hybrid Homo sapiens
61 ZMYND8 23613
Affinity Capture-MS Homo sapiens
62 NR2F1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
63 HAT1 8520
Affinity Capture-MS Homo sapiens
64 SIN3B  
Affinity Capture-MS Homo sapiens
65 MBD3L1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 GATAD2A 54815
Affinity Capture-MS Homo sapiens
67 PARP1 142
Proximity Label-MS Homo sapiens
68 UBXN4 23190
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 SAP130  
Affinity Capture-MS Homo sapiens
70 SIN3A  
Affinity Capture-MS Homo sapiens
71 PHF12  
Affinity Capture-MS Homo sapiens
72 MTA1 9112
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
73 PIN1 5300
Two-hybrid Homo sapiens
74 DPY30 84661
Affinity Capture-MS Homo sapiens
75 MORF4L2  
Two-hybrid Homo sapiens
76 HDAC1 3065
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
77 CHD4 1108
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
78 CDK6 1021
Biochemical Activity Homo sapiens
79 PAX9  
Proximity Label-MS Homo sapiens
80 SIRT1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
81 NCK2 8440
Two-hybrid Homo sapiens
82 HMGXB4 10042
Affinity Capture-MS Homo sapiens
83 EZH2  
Affinity Capture-MS Homo sapiens
84 CDK4 1019
Biochemical Activity Homo sapiens
85 MTA3 57504
Affinity Capture-MS Homo sapiens
86 GATAD1  
Affinity Capture-MS Homo sapiens
87 CHAF1B  
Affinity Capture-MS Homo sapiens
88 PWWP2A  
Affinity Capture-MS Homo sapiens
89 RBBP4 5928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 FBXO38 81545
Proximity Label-MS Homo sapiens
91 LIN37  
Affinity Capture-MS Homo sapiens
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