Gene description for BCL11A
Gene name B-cell CLL/lymphoma 11A (zinc finger protein)
Gene symbol BCL11A
Other names/aliases BCL11A-L
BCL11A-S
BCL11A-XL
BCL11a-M
CTIP1
EVI9
HBFQTL5
ZNF856
Species Homo sapiens
 Database cross references - BCL11A
ExoCarta ExoCarta_53335
Entrez Gene 53335
HGNC 13221
MIM 606557
UniProt Q9H165  
 BCL11A identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for BCL11A
Molecular Function
    metal ion binding GO:0046872 IEA
    transcription corepressor activity GO:0003714 IEA
    protein homodimerization activity GO:0042803 TAS
    protein binding GO:0005515 IPI
    protein heterodimerization activity GO:0046982 IPI
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0001078 IDA
Biological Process
    protein sumoylation GO:0016925 ISS
    negative regulation of neuron projection development GO:0010977 IDA
    negative regulation of collateral sprouting GO:0048671 IMP
    positive regulation of neuron projection development GO:0010976 IDA
    transcription, DNA-templated GO:0006351 IEA
    T cell differentiation GO:0030217 IEA
    B cell differentiation GO:0030183 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISS
    negative regulation of dendrite development GO:2000171 IMP
    regulation of dendrite development GO:0050773 IMP
    negative regulation of protein homooligomerization GO:0032463 IC
    positive regulation of collateral sprouting GO:0048672 IMP
    negative regulation of axon extension GO:0030517 ISS
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 ISS
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified BCL11A in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for BCL11A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NR2F2  
Invitro Homo sapiens
Two-hybrid Homo sapiens
2 NR2F1  
Invitro Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which BCL11A is involved
No pathways found





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