Gene description for MSL1
Gene name male-specific lethal 1 homolog (Drosophila)
Gene symbol MSL1
Other names/aliases MSL-1
hMSL1
Species Homo sapiens
 Database cross references - MSL1
ExoCarta ExoCarta_339287
Entrez Gene 339287
HGNC 27905
MIM 614801
UniProt Q68DK7  
 MSL1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for MSL1
Biological Process
    chromatin organization GO:0006325 TAS
    histone H4-K16 acetylation GO:0043984 IDA
Subcellular Localization
    MSL complex GO:0072487 IDA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified MSL1 in exosomes
1
Experiment ID 224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for MSL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MSL1 is involved
PathwayEvidenceSource
HATs acetylate histones TAS Reactome





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