Gene description for INPP4B
Gene name inositol polyphosphate-4-phosphatase, type II, 105kDa
Gene symbol INPP4B
Other names/aliases -
Species Homo sapiens
 Database cross references - INPP4B
ExoCarta ExoCarta_8821
Entrez Gene 8821
HGNC 6075
MIM 607494
UniProt O15327  
 INPP4B identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for INPP4B
Molecular Function
    phosphatidylinositol trisphosphate phosphatase activity GO:0034594 IEA
    phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity GO:0016316 IEA
    phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity GO:0034597 IEA
    protein binding GO:0005515 IPI
    lipid binding GO:0008289 IEA
Biological Process
    cellular calcium ion homeostasis GO:0006874 IEA
    regulation of bone remodeling GO:0046850 IEA
    signal transduction GO:0007165 TAS
    negative regulation of osteoclast differentiation GO:0045671 IEA
    phosphatidylinositol biosynthetic process GO:0006661 TAS
    regulation of nucleocytoplasmic transport GO:0046822 IEA
    dephosphorylation GO:0016311 IEA
    small molecule metabolic process GO:0044281 TAS
    phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 TAS
    regulation of protein kinase B signaling GO:0051896 IEA
    phospholipid metabolic process GO:0006644 TAS
    inositol phosphate metabolic process GO:0043647 TAS
Subcellular Localization
    Golgi apparatus GO:0005794 IEA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified INPP4B in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for INPP4B
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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