Gene description for Cdh2
Gene name cadherin 2
Gene symbol Cdh2
Other names/aliases CDHN
N-cadherin
Ncad
Species Mus musculus
 Database cross references - Cdh2
ExoCarta ExoCarta_12558
Vesiclepedia VP_12558
Entrez Gene 12558
UniProt P15116  
 Cdh2 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
Melanoma cells 34957415    
Melanoma cells 34957415    
Melanoma cells 34957415    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Cdh2
Molecular Function
    protein kinase binding GO:0019901 ISO
    metal ion binding GO:0046872 IEA
    protein complex binding GO:0032403 ISO
    protein phosphatase binding GO:0019903 IPI
    alpha-catenin binding GO:0045294 ISO
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    nitric-oxide synthase binding GO:0050998 ISO
    beta-catenin binding GO:0008013 ISO
    enzyme binding GO:0019899 IPI
    gamma-catenin binding GO:0045295 ISO
Biological Process
    regulation of Rho protein signal transduction GO:0035023 ISO
    positive regulation of synaptic vesicle clustering GO:2000809 IMP
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 IDA
    regulation of axonogenesis GO:0050770 ISO
    regulation of myelination GO:0031641 ISO
    neuroligin clustering involved in postsynaptic membrane assembly GO:0097118 IMP
    negative regulation of canonical Wnt signaling pathway GO:0090090 IGI
    cell-cell adhesion mediated by cadherin GO:0044331 IDA
    protein heterooligomerization GO:0051291 ISO
    regulation of signal transduction GO:0009966 IEA
    regulation of protein localization GO:0032880 ISO
    regulation of postsynaptic density protein 95 clustering GO:1902897 IMP
    blood vessel morphogenesis GO:0048514 IMP
    glial cell differentiation GO:0010001 IDA
    calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339 ISO
    single organismal cell-cell adhesion GO:0016337 ISO
    striated muscle cell differentiation GO:0051146 IGI
    cell adhesion GO:0007155 IDA
    cell migration GO:0016477 IDA
    neuronal stem cell maintenance GO:0097150 IDA
    synapse assembly GO:0007416 ISO
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IDA
    positive regulation of MAPK cascade GO:0043410 IGI
Subcellular Localization
    lamellipodium GO:0030027 ISO
    synapse GO:0045202 ISO
    cortical actin cytoskeleton GO:0030864 ISO
    plasma membrane GO:0005886 ISO
    extracellular exosome GO:0070062 ISO
    protein complex GO:0043234 ISO
    integral component of membrane GO:0016021 IEA
    intercalated disc GO:0014704 ISO
    apical plasma membrane GO:0016324 IDA
    T-tubule GO:0030315 ISO
    fascia adherens GO:0005916 ISO
    focal adhesion GO:0005925 ISO
    catenin complex GO:0016342 ISO
    membrane GO:0016020 ISO
    adherens junction GO:0005912 IDA
    cell-cell adherens junction GO:0005913 ISO
    cell-cell junction GO:0005911 ISO
    basolateral plasma membrane GO:0016323 IDA
 Experiment description of studies that identified Cdh2 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 1101
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd81|Cd9|Tfrc|Gapdh|Lamp1
EV Enriched markers
✔
GOLGA2|CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H.
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 1102
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd81|Cd9|Tfrc|Gapdh|Lamp1
EV Enriched markers
✔
GOLGA2|CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H.
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F10
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
Flow cytometry
4
Experiment ID 1103
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd81|Cd9|Tfrc|Gapdh|Lamp1
EV Enriched markers
✔
GOLGA2|CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H.
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1R2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
Flow cytometry
5
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cdh2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 N/A  
Affinity Capture-Western Mus musculus
View the network image/svg+xml
 Pathways in which Cdh2 is involved
PathwayEvidenceSource
Adherens junctions interactions IEA Reactome
CDO in myogenesis IEA Reactome





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