Gene description for Ptprk
Gene name protein tyrosine phosphatase, receptor type, K
Gene symbol Ptprk
Other names/aliases AI853699
PTPk
RPTPkappa
Species Mus musculus
 Database cross references - Ptprk
ExoCarta ExoCarta_19272
Entrez Gene 19272
UniProt P35822  
 Ptprk identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ptprk
Molecular Function
    protein tyrosine phosphatase activity GO:0004725 ISO
    hydrolase activity GO:0016787 IEA
    beta-catenin binding GO:0008013 ISO
    protein kinase binding GO:0019901 ISO
    gamma-catenin binding GO:0045295 ISO
    phosphatase activity GO:0016791 IEA
    phosphoprotein phosphatase activity GO:0004721 IEA
Biological Process
    cell migration GO:0016477 ISO
    focal adhesion assembly GO:0048041 ISO
    dephosphorylation GO:0016311 IEA
    protein localization to cell surface GO:0034394 ISO
    negative regulation of transcription, DNA-templated GO:0045892 ISO
    cell adhesion GO:0007155 ISO
    transforming growth factor beta receptor signaling pathway GO:0007179 ISO
    protein dephosphorylation GO:0006470 ISO
    cellular response to UV GO:0034644 ISO
    negative regulation of cell migration GO:0030336 ISO
    signal transduction GO:0007165 ISO
    cellular response to reactive oxygen species GO:0034614 ISO
    negative regulation of cell proliferation GO:0008285 ISO
    negative regulation of cell cycle GO:0045786 ISO
    negative regulation of keratinocyte proliferation GO:0010839 ISO
    peptidyl-tyrosine dephosphorylation GO:0035335 ISO
    neuron projection development GO:0031175 ISO
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    photoreceptor outer segment GO:0001750 IDA
    membrane GO:0016020 IEA
    dendrite GO:0030425 IDA
    axon GO:0030424 IDA
    cell-cell junction GO:0005911 ISO
    leading edge membrane GO:0031256 ISO
    cell surface GO:0009986 ISO
    neuronal cell body GO:0043025 IDA
 Experiment description of studies that identified Ptprk in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ptprk
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ptprk is involved
No pathways found





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