Gene description for PITPNA
Gene name phosphatidylinositol transfer protein, alpha
Gene symbol PITPNA
Other names/aliases HEL-S-36
PI-TPalpha
PITPN
VIB1A
Species Homo sapiens
 Database cross references - PITPNA
ExoCarta ExoCarta_5306
Entrez Gene 5306
HGNC 9001
MIM 600174
UniProt Q00169  
 PITPNA identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for PITPNA
Molecular Function
    phosphatidylinositol transporter activity GO:0008526 TAS
    phosphatidylcholine transporter activity GO:0008525 TAS
    lipid binding GO:0008289 IEA
Biological Process
    phospholipid transport GO:0015914 TAS
    axon guidance GO:0007411 TAS
    lipid metabolic process GO:0006629 NAS
    visual perception GO:0007601 TAS
Subcellular Localization
    cytoplasm GO:0005737 IEA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified PITPNA in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PITPNA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MLKL  
Affinity Capture-MS Homo sapiens
2 MORF4L2  
Affinity Capture-MS Homo sapiens
3 PLCG1 5335
Invivo Homo sapiens
Invitro Homo sapiens
4 EGFR 1956
Invivo Homo sapiens
Invitro Homo sapiens
5 PMVK 10654
Affinity Capture-MS Homo sapiens
6 SCP2  
FRET Homo sapiens
View the network image/svg+xml
 Pathways in which PITPNA is involved
PathwayEvidenceSource
Role of second messengers in netrin-1 signaling TAS Reactome





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