Gene description for LPIN1
Gene name lipin 1
Gene symbol LPIN1
Other names/aliases PAP1
Species Homo sapiens
 Database cross references - LPIN1
ExoCarta ExoCarta_23175
Vesiclepedia VP_23175
Entrez Gene 23175
HGNC 13345
MIM 605518
UniProt Q14693  
 LPIN1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for LPIN1
Molecular Function
    molecular_function GO:0003674 ND
    histone deacetylase binding GO:0042826 IEA
    RNA polymerase II transcription factor binding GO:0001085 IEA
    phosphatidate phosphatase activity GO:0008195 IBA
    transcription coactivator activity GO:0003713 IBA
    peroxisome proliferator activated receptor binding GO:0042975 IEA
Biological Process
    phosphatidylethanolamine biosynthetic process GO:0006646 TAS
    cellular lipid metabolic process GO:0044255 TAS
    ruffle organization GO:0031529 IEA
    actin cytoskeleton reorganization GO:0031532 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IBA
    small molecule metabolic process GO:0044281 TAS
    mitochondrial fission GO:0000266 IEA
    phospholipid metabolic process GO:0006644 TAS
    positive regulation of histone deacetylation GO:0031065 IEA
    mitotic nuclear envelope disassembly GO:0007077 TAS
    triglyceride biosynthetic process GO:0019432 TAS
    triglyceride mobilization GO:0006642 ISS
    regulation of fat cell differentiation GO:0045598 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA
    glycerophospholipid biosynthetic process GO:0046474 TAS
    organ regeneration GO:0031100 IEA
    phosphatidylcholine biosynthetic process GO:0006656 TAS
    transcription, DNA-templated GO:0006351 IEA
    dephosphorylation GO:0016311 IEA
    fatty acid catabolic process GO:0009062 ISS
    mitotic cell cycle GO:0000278 TAS
    cellular response to insulin stimulus GO:0032869 IEA
Subcellular Localization
    nuclear envelope GO:0005635 TAS
    endoplasmic reticulum membrane GO:0005789 TAS
    cytosol GO:0005829 IEA
    nucleoplasm GO:0005654 TAS
    transcription factor complex GO:0005667 IEA
    mitochondrial outer membrane GO:0005741 IBA
    cytoplasm GO:0005737 ISS
    nuclear membrane GO:0031965 ISS
    nucleus GO:0005634 ISS
 Experiment description of studies that identified LPIN1 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LPIN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which LPIN1 is involved
PathwayEvidenceSource
Depolymerisation of the Nuclear Lamina TAS Reactome
Synthesis of PC TAS Reactome
Synthesis of PE TAS Reactome
Triglyceride Biosynthesis TAS Reactome





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