Gene description for BCAR3
Gene name breast cancer anti-estrogen resistance 3
Gene symbol BCAR3
Other names/aliases NSP2
SH2D3B
Species Homo sapiens
 Database cross references - BCAR3
ExoCarta ExoCarta_8412
Vesiclepedia VP_8412
Entrez Gene 8412
HGNC 973
MIM 604704
UniProt O75815  
 BCAR3 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for BCAR3
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IEA
    protein binding GO:0005515 IPI
Biological Process
    lens morphogenesis in camera-type eye GO:0002089 IEA
    positive regulation of peptidyl-serine phosphorylation GO:0033138 IEA
    response to drug GO:0042493 TAS
    signal transduction GO:0007165 TAS
    positive regulation of GTPase activity GO:0043547 IEA
    small GTPase mediated signal transduction GO:0007264 IEA
Subcellular Localization
    intracellular GO:0005622 IEA
 Experiment description of studies that identified BCAR3 in exosomes
1
Experiment ID 488
MISEV standards
EM
EV Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
CANX
EV Negative markers
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for BCAR3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IMPDH2 3615
Affinity Capture-MS Homo sapiens
2 NEDD9 4739
Affinity Capture-Western Homo sapiens
3 BCAR1 9564
Affinity Capture-Western Homo sapiens
4 IARS 3376
Affinity Capture-MS Homo sapiens
5 PABPC1 26986
Affinity Capture-MS Homo sapiens
6 TARS 6897
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which BCAR3 is involved
No pathways found





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