Gene description for SLC26A4
Gene name solute carrier family 26 (anion exchanger), member 4
Gene symbol SLC26A4
Other names/aliases DFNB4
EVA
PDS
TDH2B
Species Homo sapiens
 Database cross references - SLC26A4
ExoCarta ExoCarta_5172
Vesiclepedia VP_5172
Entrez Gene 5172
HGNC 8818
MIM 605646
UniProt O43511  
 SLC26A4 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
Urine 21082674    
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for SLC26A4
Molecular Function
    protein binding GO:0005515 IPI
    secondary active sulfate transmembrane transporter activity GO:0008271 IEA
    bicarbonate transmembrane transporter activity GO:0015106 IBA
    chloride transmembrane transporter activity GO:0015108 IBA
    chloride transmembrane transporter activity GO:0015108 IDA
    chloride transmembrane transporter activity GO:0015108 IMP
    iodide transmembrane transporter activity GO:0015111 IDA
    iodide transmembrane transporter activity GO:0015111 IMP
    iodide transmembrane transporter activity GO:0015111 TAS
    sulfate transmembrane transporter activity GO:0015116 IBA
    oxalate transmembrane transporter activity GO:0019531 IBA
    chloride:bicarbonate antiporter activity GO:0140900 IDA
    chloride:bicarbonate antiporter activity GO:0140900 IMP
Biological Process
    monoatomic ion transport GO:0006811 TAS
    regulation of pH GO:0006885 ISS
    sensory perception of sound GO:0007605 TAS
    inorganic anion transport GO:0015698 TAS
    bicarbonate transport GO:0015701 IEA
    iodide transport GO:0015705 IMP
    oxalate transport GO:0019532 IEA
    regulation of protein localization GO:0032880 ISS
    sulfate transmembrane transport GO:1902358 IBA
    chloride transmembrane transport GO:1902476 IBA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IMP
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 TAS
    apical plasma membrane GO:0016324 IDA
    apical plasma membrane GO:0016324 ISS
    brush border membrane GO:0031526 ISS
    extracellular exosome GO:0070062 HDA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified SLC26A4 in exosomes
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
2
Experiment ID 102
MISEV standards
IEM
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21082674    
Organism Homo sapiens
Experiment description "Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS."
Authors "Zhang Y, Li Y, Qiu F, Qiu Z."
Journal name ELEC
Publication year 2010
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Immunoelectron Microscopy
3
Experiment ID 196
MISEV standards
EM
Biophysical techniques
Alix|TSG101|HSP70|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 197
MISEV standards
EM
Biophysical techniques
Alix|TSG101|HSP70|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SLC26A4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATP2B3 492
Affinity Capture-MS Homo sapiens
2 OR11G2  
Affinity Capture-MS Homo sapiens
3 TMEM164  
Affinity Capture-MS Homo sapiens
4 FNDC3A 22862
Affinity Capture-MS Homo sapiens
5 ATP6V0A1 535
Affinity Capture-MS Homo sapiens
6 ATP12A 479
Affinity Capture-MS Homo sapiens
7 TMEM55A 55529
Affinity Capture-MS Homo sapiens
8 MAD2L1BP  
Affinity Capture-MS Homo sapiens
9 MAD2L1 4085
Affinity Capture-MS Homo sapiens
10 ATP2A3 489
Affinity Capture-MS Homo sapiens
11 OMA1  
Affinity Capture-MS Homo sapiens
12 SCCPDH 51097
Affinity Capture-MS Homo sapiens
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