Gene description for SGPP1
Gene name sphingosine-1-phosphate phosphatase 1
Gene symbol SGPP1
Other names/aliases SPPase1
Species Homo sapiens
 Database cross references - SGPP1
ExoCarta ExoCarta_81537
Vesiclepedia VP_81537
Entrez Gene 81537
HGNC 17720
MIM 612826
UniProt Q9BX95  
 SGPP1 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for SGPP1
Molecular Function
    sphingosine-1-phosphate phosphatase activity GO:0042392 IBA
    sphingosine-1-phosphate phosphatase activity GO:0042392 IDA
    sphingosine-1-phosphate phosphatase activity GO:0042392 TAS
    dihydrosphingosine-1-phosphate phosphatase activity GO:0070780 IEA
Biological Process
    sphinganine-1-phosphate metabolic process GO:0006668 IEA
    sphingosine metabolic process GO:0006670 IBA
    sphingolipid catabolic process GO:0030149 TAS
    ER to Golgi ceramide transport GO:0035621 IMP
    regulation of keratinocyte differentiation GO:0045616 ISS
    regulation of epidermis development GO:0045682 ISS
    phospholipid dephosphorylation GO:0046839 IBA
    extrinsic apoptotic signaling pathway GO:0097191 IEA
    intrinsic apoptotic signaling pathway GO:0097193 IEA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 TAS
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified SGPP1 in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SGPP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CRELD1 78987
Affinity Capture-MS Homo sapiens
2 MAS1  
Affinity Capture-MS Homo sapiens
3 SLC22A16 85413
Affinity Capture-MS Homo sapiens
4 SLC15A1  
Affinity Capture-MS Homo sapiens
5 PTH1R  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 GABRE  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 LAMP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 TMEM63B 55362
Affinity Capture-MS Homo sapiens
9 TUBG1 7283
Affinity Capture-MS Homo sapiens
10 LRRC55  
Affinity Capture-MS Homo sapiens
11 MCOLN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 ASIC4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 SLC39A8 64116
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 GOLT1B 51026
Affinity Capture-MS Homo sapiens
15 ERGIC3 51614
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 P2RY2 5029
Affinity Capture-MS Homo sapiens
17 GCGR  
Affinity Capture-MS Homo sapiens
18 UBC 7316
Reconstituted Complex Homo sapiens
19 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
20 DLK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 SLAMF1 6504
Affinity Capture-MS Homo sapiens
22 SLC22A9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 SYP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 CHST10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 GP5 2814
Affinity Capture-MS Homo sapiens
26 GPR114  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 GDPD5 81544
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 SCGN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 S1PR4  
Affinity Capture-MS Homo sapiens
30 GPR182  
Affinity Capture-MS Homo sapiens
31 TCTN2  
Affinity Capture-MS Homo sapiens
32 TM2D2 83877
Affinity Capture-MS Homo sapiens
33 SERBP1 26135
Affinity Capture-MS Homo sapiens
34 PTH2R  
Affinity Capture-MS Homo sapiens
35 YIPF3 25844
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 LRRN4CL 221091
Affinity Capture-MS Homo sapiens
37 SLC22A4 6583
Affinity Capture-MS Homo sapiens
38 RHOT2 89941
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 ATP2A3 489
Affinity Capture-MS Homo sapiens
40 CMKLR1 1240
Affinity Capture-MS Homo sapiens
41 SLC7A1 6541
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SGPP1 is involved
PathwayEvidenceSource
Metabolism TAS Reactome
Metabolism of lipids TAS Reactome
Sphingolipid catabolism TAS Reactome
Sphingolipid metabolism TAS Reactome





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